Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96BN8 / OTUL_HUMAN
Protein Name Ubiquitin thioesterase otulin
Gene Name Name: OTULIN
Synonyms:FAM105B;
Organism Homo sapiens (Human)

PRO ID PR:Q96BN8
DAG View
PRO Name ubiquitin thioesterase otulin (human)
Definition A ubiquitin thioesterase otulin that is encoded in the genome of human.
Short Label hOTULIN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96BN8 (OTULIN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C17 S-Nitrosylation dbSNO 26338901
K34 Ubiquitination PhosphoSitePlus
C47 S-Nitrosylation dbSNO 26338901
Y56 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24726323, 31825842, 32770022, ...24726327
K64 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K187 Acetylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T104 M104 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K164 R164 Biomuta DOID:363 / uterine cancer [ tcga ]
K180 E180 Biomuta DOID:3571 / liver cancer [ tcga ]