iPTMnet Report for Q96B97 (SH3KBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96B97 / SH3K1_HUMAN
Protein Name SH3 domain-containing kinase-binding protein 1
Gene Name Name: SH3KBP1
Synonyms:CIN85;
Organism Homo sapiens (Human)

PRO ID PR:Q96B97
DAG View
PRO Name SH3 domain-containing kinase-binding protein 1 (human)
Definition An SH3 domain-containing kinase-binding protein 1 that is encoded in the genome of human.
Short Label hSH3KBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96B97 (SH3KBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K57 Acetylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus   UniProt 24275569
S193 Phosphorylation PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
S230 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15144186, 19367720, 18669648, 19690332, 20068231
K242 Ubiquitination PhosphoSitePlus
T243 Phosphorylation IEDB 35494241
T251 O-Glycosylation GlyGen 31373491
T252 Phosphorylation PhosphoSitePlus
T254 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S344 Phosphorylation PhosphoSitePlus
K349 Methylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
S436 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K438 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K452 Ubiquitination PhosphoSitePlus
S468 O-Glycosylation GlyGen 31373491
S471 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...31373491
S472 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...31373491
S472 Phosphorylation PhosphoSitePlus
T473 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K475 Ubiquitination PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
S509 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S511 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S521 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K535 Acetylation PhosphoSitePlus
T536 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...31373491
T536 Phosphorylation PhosphoSitePlus
T538 O-Glycosylation GlyGen 31373491
T538 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
K546 Acetylation PhosphoSitePlus
T555 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...31373491
S567 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...31373491
S572 O-Glycosylation GlyGen 31373491
S572 Phosphorylation PhosphoSitePlus
S575 O-Glycosylation GlyGen 31373491
S576 O-Glycosylation GlyGen 31373491
S577 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
S587 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16083285, 23186163, ...20068231
S589 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
K598 Sumoylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S639 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD 20166139
S82 Phosphorylation HPRD 20166139
S230 Phosphorylation HPRD 19664994, 20058876, 15144186, ...18452278, 19651622, 18669648, 20068231
T254 Phosphorylation HPRD 18669648
S436 Phosphorylation HPRD 19651622, 18669648, 20068231
S447 Phosphorylation HPRD 18669648
S472 Phosphorylation HPRD 18452278
T473 Phosphorylation HPRD 18669648
S509 Phosphorylation HPRD 18669648, 17081983
S511 Phosphorylation HPRD 19651622, 18669648, 17081983
S521 Phosphorylation HPRD 18669648
T536 Phosphorylation HPRD 18077418
T538 Phosphorylation HPRD 18077418
S540 Phosphorylation HPRD 18077418
S587 Phosphorylation HPRD 16083285, 20058876, 19664994, ...18452278, 19651622, 18669648, 19415658, 20068231
S589 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S42 Phosphorylation HPRD 20166139
S45 Phosphorylation HPRD 20166139
S193 Phosphorylation HPRD 19664994, 20058876, 15144186, ...18452278, 19651622, 18669648, 20068231
T217 Phosphorylation HPRD 18669648
S399 Phosphorylation HPRD 19651622, 18669648, 20068231
S410 Phosphorylation HPRD 18669648
S435 Phosphorylation HPRD 18452278
T436 Phosphorylation HPRD 18669648
S472 Phosphorylation HPRD 18669648, 17081983
S474 Phosphorylation HPRD 19651622, 18669648, 17081983
S484 Phosphorylation HPRD 18669648
T499 Phosphorylation HPRD 18077418
T501 Phosphorylation HPRD 18077418
S503 Phosphorylation HPRD 18077418
S550 Phosphorylation HPRD 16083285, 20058876, 19664994, ...18452278, 19651622, 18669648, 19415658, 20068231
S552 Phosphorylation HPRD 19651622


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049228 (hSH3KBP1/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P22681 (CBL) Y731 Q96B97 (SH3KBP1) inhibited_association eFIP 33627783


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S42 R42 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S42 I42 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S79 R79 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S79 I79 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S85 F85 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S85 C85 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S159 L159 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S165 F165 Biomuta DOID:4159 / skin cancer [ cosmic ]
T179 A179 Biomuta DOID:1324 / lung cancer [ cosmic ]
S193 Y193 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K401 T401 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T436 A436 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K438 N438 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S445 L445 Biomuta DOID:4159 / skin cancer [ cosmic ]
S468 P468 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S468 Y468 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S472 P472 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T473 A473 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S493 F493 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S495 F495 Biomuta DOID:4159 / skin cancer [ cosmic ]
S498 F498 Biomuta DOID:363 / uterine cancer [ icgc ]
T499 S499 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S503 Y503 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S509 P509 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T536 S536 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S540 Y540 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S552 Y552 Biomuta DOID:363 / uterine cancer [ icgc ]
S577 P577 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S589 Y589 Biomuta DOID:363 / uterine cancer [ icgc ]
K598 N598 Biomuta DOID:363 / uterine cancer [ icgc ]