Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96B36 / AKTS1_HUMAN
Protein Name Proline-rich AKT1 substrate 1
Gene Name Name: AKT1S1
Synonyms:PRAS40;
Organism Homo sapiens (Human)

PRO ID PR:Q96B36
DAG View
PRO Name proline-rich AKT1 substrate 1 (human)
Definition A proline-rich AKT1 substrate 1 that is encoded in the genome of human.
Short Label hAKT1S1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96B36 (AKT1S1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T32 Phosphorylation PhosphoSitePlus
R40 Methylation PhosphoSitePlus
R51 Methylation PhosphoSitePlus   UniProt 24129315
T73 Phosphorylation PhosphoSitePlus
S88 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...18669648, 24275569, 19690332
T90 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S92 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...18669648, 24275569, 19690332
T97 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S183 Phosphorylation P42345 (MTOR) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 17081983, ...25311616, 19835147, 18669648, 18372248, 17517883, 27988363, 25961827, 19690332, 20068231
T198 Phosphorylation PhosphoSitePlus
S202 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17081983, 18669648, 26876154, ...24275569, 19690332, 20068231
S203 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 18669648, ...26876154, 24275569, 20068231
S211 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 19690332, 20068231
S221 Phosphorylation P42345 (MTOR) PhosphoSitePlus   RLIMS-P 24704832, 18372248
T246 Phosphorylation P11309 (PIM1) , P31749 (AKT1) , P31751 (AKT2) , O43781 (DYRK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23415227, 19276681, 25876175, ...28071670, 18030348, 24701227, 20484410, 26497682, 24704832, 20068231, 21406692, 23029019, 21698202, 25961827, 19690332, 20686178, 17277771, 12524439, 28674187, 20145103, 29634919, 18220336, 22879939, 21592956, 25136826, 17081983, 18215133, 25311616, 18669648, 26876154, 17130464, 28303961, 24316235
S247 Phosphorylation PhosphoSitePlus
K251 Methylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T73 Phosphorylation HPRD 19651622
S88 Phosphorylation HPRD 17287340, 20230923, 19651622, ...18669648, 20166139, 20068231
T90 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231, 20230923
S92 Phosphorylation HPRD 17287340, 20230923, 19651622, ...18669648, 20166139, 20068231
T97 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231
S183 Phosphorylation HPRD 19413330, 18212344, 19664995, ...19651622, 18669648, 18707149, 20068231
T198 Phosphorylation HPRD 19413330
S202 Phosphorylation HPRD 19413330, 18452278, 19651622, ...18669648, 19415658, 20068231
S203 Phosphorylation HPRD 19413330, 18452278, 19651622, ...18669648, 19415658, 20068231
S211 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S212 Phosphorylation HPRD 19413330, 18767875, 18452278, ...19651622, 18669648, 19415658, 20068231
T246 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96B36 (AKT1S1) T246 Q68ED7 (Crtc1) unknown eFIP 18215133
Phosphorylation Q96B36 (AKT1S1) T246 P62913 (RPL11) increased_association eFIP 24704832
Phosphorylation Q96B36 (AKT1S1) S221 P62913 (RPL11) increased_association eFIP 24704832
Phosphorylation Q96B36 (AKT1S1) S183 Q68ED7 (Crtc1) unknown eFIP 25311616
Phosphorylation Q96B36 (AKT1S1) T246 Q68ED7 (Crtc1) unknown eFIP 25311616


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R51 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S92 I92 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T198 A198 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S203 L203 Biomuta DOID:4362 / cervical cancer [ tcga ]
S212 L212 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]