iPTMnet Report for Q96AY2 (EME1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96AY2 / EME1_HUMAN
Protein Name Crossover junction endonuclease EME1
Gene Name Name: EME1
Synonyms:MMS4;
Organism Homo sapiens (Human)

PRO ID PR:Q96AY2
DAG View
PRO Name crossover junction endonuclease EME1 (human)
Definition A crossover junction endonuclease EME1 that is encoded in the genome of human.
Short Label hEME1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96AY2 (EME1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S7 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S9 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S15 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163
S17 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T33 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S84 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S85 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 15302935, ...18669648, 20068231
S87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
K103 Sumoylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S117 Phosphorylation PhosphoSitePlus   UniProt 20068231
S132 Phosphorylation PhosphoSitePlus
K136 Sumoylation PhosphoSitePlus
T150 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
C166 Methylation IEDB 33981976
K232 Sumoylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
C289 Methylation IEDB 31844290
K329 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
K338 Methylation PhosphoSitePlus
K338 Sumoylation PhosphoSitePlus
K340 Methylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 18669648, 17081983
S7 Phosphorylation HPRD 18669648, 17081983, 20068231
S9 Phosphorylation HPRD 18669648, 17081983
S12 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S15 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
S17 Phosphorylation HPRD 18669648, 17081983, 18452278
S84 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S85 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231, 18452278
S87 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S111 Phosphorylation HPRD 19413330, 20068231
S117 Phosphorylation HPRD 19413330, 19664995, 20068231
T150 Phosphorylation HPRD 18669648, 20068231
S332 Phosphorylation HPRD 18452278
T336 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 18669648, 17081983
S7 Phosphorylation HPRD 18669648, 17081983, 20068231
S9 Phosphorylation HPRD 18669648, 17081983
S12 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S15 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
S17 Phosphorylation HPRD 18669648, 17081983, 18452278
S84 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S85 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231, 18452278
S87 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S111 Phosphorylation HPRD 19413330, 20068231
S117 Phosphorylation HPRD 19413330, 19664995, 20068231
T150 Phosphorylation HPRD 18669648, 20068231
S332 Phosphorylation HPRD 18452278
T336 Phosphorylation HPRD 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96NY9 (MUS81) S87 Q96AY2 (EME1) inhibited_association eFIP 29850896


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 L6 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S7 L7 Biomuta DOID:4159 / skin cancer [ cosmic ]
S9 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S9 P9 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, cosmic, icgc, cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S84 I84 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S85 N85 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S111 N111 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S117 F117 Biomuta DOID:4159 / skin cancer [ cosmic ]
K232 T232 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K232 N232 Biomuta DOID:9256 / colorectal cancer [ cosmic ]