iPTMnet Report for Q96AD5 (PNPLA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96AD5 / PLPL2_HUMAN
Protein Name Patatin-like phospholipase domain-containing protein 2
Gene Name Name: PNPLA2
Synonyms:ATGL;ORFNames:FP17548;
Organism Homo sapiens (Human)

PRO ID PR:Q96AD5
DAG View
PRO Name patatin-like phospholipase domain-containing protein 2 (human)
Definition A patatin-like phospholipase domain-containing protein 2 that is encoded in the genome of human.
Short Label hPNPLA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96AD5 (PNPLA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C28 Methylation IEDB 31844290
K74 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus   UniProt 34903883
K100 Ubiquitination PhosphoSitePlus
T119 O-Glycosylation GlyGen 29351928
K224 Ubiquitination PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S404 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22713505, 23186163, 18669648, ...22733971, 26091039
S407 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
C412 Methylation IEDB 31844290
S428 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...24275569
K435 Ubiquitination PhosphoSitePlus
C439 Methylation IEDB 31844290
S476 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S404 Phosphorylation HPRD 18767875, 18669648
S428 Phosphorylation HPRD 19651622, 18767875, 18669648, ...19664994, 20058876


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96AD5 (PNPLA2) S404 Q13131 (PRKAA1) increased_association eFIP 22713505


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S407 F407 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C412 R412 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K435 T435 Biomuta DOID:4159 / skin cancer [ cosmic ]
C439 Y439 Biomuta DOID:363 / uterine cancer [ icgc ]
S476 F476 Biomuta DOID:1612 / breast cancer [ cosmic ]