iPTMnet Report for Q96A08 (H2BC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96A08 / H2B1A_HUMAN
Protein Name Histone H2B type 1-A
Gene Name Name: H2BC1
Synonyms:HIST1H2BA;
Organism Homo sapiens (Human)

PRO ID PR:Q96A08
DAG View
PRO Name histone H2B type 1-A (human)
Definition A histone H2B type 1-A that is encoded in the genome of human.
Short Label hH2BC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96A08 (H2BC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
M1 Acetylation PRO
K7 Acetylation PRO   UniProt 16283522
K13 Acetylation PhosphoSitePlus
K14 Acetylation PRO   UniProt 16283522
K17 Acetylation PRO   PhosphoSitePlus   UniProt 16283522
K22 Acetylation PRO   UniProt 16283522
S57 Phosphorylation PhosphoSitePlus
R81 Methylation UniProt 21249133
S86 Phosphorylation UniProt 21249133
K87 Acetylation UniProt 21249133
R88 Methylation UniProt 21249133
S92 Phosphorylation PhosphoSitePlus
R94 Methylation UniProt 21249133
K122 Ubiquitination PRO   UniProt 16713563, 16307923


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036256 (hHIST1H2BA/Ac:1) acM1 PRO
PR:000047754 (hHIST1H2BA/InitMet-/Ac:2) acK14 PRO
PR:000047755 (hHIST1H2BA/InitMet-/Ac:3) acK17 PRO
PR:000047756 (hHIST1H2BA/InitMet-/Ac:4) acK22 PRO
PR:000047757 (hHIST1H2BA/InitMet-/Ac:5) acK7 PRO
PR:000047758 (hHIST1H2BA/InitMet-/N6AcLys+) ac PRO
PR:000047760 (hHIST1H2BA/InitMet-/Ubiq:2) ubK122 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 C57 Biomuta DOID:1612 / breast cancer [ cosmic ]
R81 C81 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S86 N86 Biomuta [ cosmic ]
R88 C88 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
R88 H88 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R88 L88 Biomuta DOID:1324 / lung cancer [ cosmic ]
S92 F92 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S92 Y92 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R94 K94 Biomuta DOID:4159 / skin cancer [ cosmic ]