Protein Information

Cytoscape View


UniProt AC / UniProt ID Q969V6 / MRTFA_HUMAN
Protein Name Myocardin-related transcription factor A
Gene Name Name: MRTFA
Synonyms:KIAA1438;
Organism Homo sapiens (Human)

PRO ID PR:Q969V6
DAG View
PRO Name myocardin-related transcription factor A (human)
Definition A myocardin-related transcription factor A that is encoded in the genome of human.
Short Label hMRTFA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q969V6 (MRTFA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
S114 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus   UniProt 23186163
T204 Phosphorylation PhosphoSitePlus
K237 Methylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
T305 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S310 Phosphorylation PhosphoSitePlus
S312 Phosphorylation P49137 (MAPKAPK2) PhosphoSitePlus   RLIMS-P+ 27492266
T313 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
C326 S-Nitrosylation dbSNO 26338901
S333 Phosphorylation P49137 (MAPKAPK2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 27492266, 18669648, 23186163, ...20068231
T334 Phosphorylation PhosphoSitePlus
S335 Phosphorylation HPRD   PhosphoSitePlus 20068231
T337 Phosphorylation PhosphoSitePlus
K351 Methylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K392 Ubiquitination PhosphoSitePlus
S416 Phosphorylation HPRD 20068231
S446 Phosphorylation PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus
S449 Phosphorylation HPRD   PhosphoSitePlus 17081983
T450 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...19664994, 19664995, 19651622, 17322306, 18669648, 20068231
S454 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 19651622, 21406692, ...17081983, 18694962, 19664995, 17322306, 18669648, 20068231, 22139079
T456 Phosphorylation PhosphoSitePlus
S458 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S470 Phosphorylation PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus
K499 Sumoylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
T573 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K576 Sumoylation PhosphoSitePlus
K624 Sumoylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S154 C154 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S302 R302 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T305 N305 Biomuta DOID:3571 / liver cancer [ icgc ]
S310 R310 Biomuta DOID:3571 / liver cancer [ icgc ]
S310 N310 Biomuta DOID:363 / uterine cancer [ tcga ]
S312 P312 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S317 N317 Biomuta DOID:363 / uterine cancer [ tcga ]
T337 N337 Biomuta DOID:3571 / liver cancer [ icgc ]
T447 M447 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
S454 C454 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K576 R576 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]