iPTMnet Report for Q969U6 (FBXW5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q969U6 / FBXW5_HUMAN
Protein Name F-box/WD repeat-containing protein 5
Gene Name Name: FBXW5
Synonyms:FBW5;ORFNames:PP3971;
Organism Homo sapiens (Human)

PRO ID PR:Q969U6
DAG View
PRO Name F-box/WD repeat-containing protein 5 (human)
Definition An F-box/WD repeat-containing protein 5 that is encoded in the genome of human.
Short Label hFBXW5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q969U6 (FBXW5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S151 Phosphorylation O00444 (PLK4) PhosphoSitePlus   RLIMS-P   UniProt 21725316
K240 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus   UniProt 23186163
K299 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S151 L151 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K240 E240 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S275 P275 Biomuta DOID:363 / uterine cancer [ icgc ]
K299 R299 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T377 M377 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]