Protein Information

Cytoscape View

UniProt AC / UniProt ID Q969R5 / LMBL2_HUMAN
Protein Name Lethal(3)malignant brain tumor-like protein 2
Gene Name Name: L3MBTL2
Organism Homo sapiens (Human)

DAG View
PRO Name lethal(3)malignant brain tumor-like protein 2 (human)
Definition A lethal(3)malignant brain tumor-like protein 2 that is encoded in the genome of human.
Short Label hL3MBTL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q969R5 (L3MBTL2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S13 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T66 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S67 Phosphorylation PhosphoSitePlus   UniProt 23186163
S73 Phosphorylation PhosphoSitePlus
T76 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S79 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S158 Phosphorylation RLIMS-P 29581593
K186 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus   RLIMS-P 29581593
S338 Phosphorylation PhosphoSitePlus   UniProt 21406692
K405 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
K675 Sumoylation PRO   PhosphoSitePlus
S683 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S688 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S689 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S695 Phosphorylation PhosphoSitePlus
K700 Sumoylation PRO   PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation HPRD 18452278
S12 Phosphorylation HPRD 18669648, 18452278
S13 Phosphorylation HPRD 18669648
T66 Phosphorylation HPRD 19651622, 20068231
S67 Phosphorylation HPRD 20068231
S79 Phosphorylation HPRD 18452278
S683 Phosphorylation HPRD 18669648, 20068231
S688 Phosphorylation HPRD 18669648, 20068231
S689 Phosphorylation HPRD 19413330, 18669648, 20068231


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048151 (hL3MBTL2/Sumo:1) suK675,suK700 PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q969R5 (L3MBTL2) S335 Q14676 (MDC1) unknown eFIP 29581593

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K186 R186 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
K191 N191 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ cosmic ]
Y230 * Biomuta DOID:363 / uterine cancer [ tcga ]
S304 F304 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K405 N405 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K537 N537 Biomuta DOID:363 / uterine cancer [ tcga ]
S662 L662 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S683 W683 Biomuta DOID:1324 / lung cancer [ tcga ]
S689 G689 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]