iPTMnet Report for Q969P6 (TOP1MT)
Protein Information
| UniProt AC / UniProt ID | Q969P6 / TOP1M_HUMAN |
| Protein Name | DNA topoisomerase I, mitochondrial precursor |
| Gene Name | Name: TOP1MT |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q969P6 |
| PRO Name | DNA topoisomerase I, mitochondrial (human) |
| Definition | A DNA topoisomerase I, mitochondrial that is encoded in the genome of human. |
| Short Label | hTOP1MT |
| Category | organism-gene |
DAG ViewQ969P6 (TOP1MT) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S31 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T34 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| K46 | Acetylation | score1 | PhosphoSitePlus | |||
| K52 | Acetylation | score1 | PhosphoSitePlus | |||
| Y96 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y104 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K112 | Acetylation | score1 | PhosphoSitePlus | |||
| K210 | Methylation | score1 | PhosphoSitePlus | |||
| S226 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y262 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T282 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y316 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K320 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K329 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y384 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T405 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T442 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T485 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K515 | Acetylation | score1 | PhosphoSitePlus | |||
| Y559 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S31 | L31 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
| K52 | T52 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K112 | N112 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S226 | L226 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S242 | C242 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| T247 | M247 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K329 | E329 | Biomuta | [ cosmic ] | |
| Y384 | H384 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T405 | P405 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| T405 | I405 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
