iPTMnet Report for Q969K3 (RNF34)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q969K3 / RNF34_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF34
Gene Name Name: RNF34
Organism Homo sapiens (Human)

PRO ID PR:Q969K3
DAG View
PRO Name E3 ubiquitin-protein ligase RNF34 (human)
Definition An E3 ubiquitin-protein ligase RNF34 that is encoded in the genome of human.
Short Label hRNF34
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q969K3 (RNF34) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Ubiquitination PhosphoSitePlus
C62 Methylation IEDB 31844290
K83 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus   UniProt 23186163
S173 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
S254 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S256 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K273 Ubiquitination PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S254 Phosphorylation HPRD 18669648, 20068231
S256 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S255 Phosphorylation HPRD 18669648, 20068231
S257 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K2 N2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S169 F169 Biomuta DOID:4159 / skin cancer [ cosmic ]
S169 P169 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K308 N308 Biomuta DOID:3571 / liver cancer [ icgc ]