iPTMnet Report for Q969H4 (CNKSR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q969H4 / CNKR1_HUMAN
Protein Name Connector enhancer of kinase suppressor of ras 1
Gene Name Name: CNKSR1
Synonyms:CNK1;
Organism Homo sapiens (Human)

PRO ID PR:Q969H4
DAG View
PRO Name connector enhancer of kinase suppressor of ras 1 (human)
Definition A connector enhancer of kinase suppressor of ras 1 that is encoded in the genome of human.
Short Label hCNKSR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q969H4 (CNKSR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus   RLIMS-P 28819643
Y26 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P 26319181
S278 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
S305 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
S307 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S314 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...16964243
S392 Phosphorylation PhosphoSitePlus
K414 Acetylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
Y519 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P 26319181
S533 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
Y665 Phosphorylation P12931 (SRC) PhosphoSitePlus 26319181
Site PTM Type PTM Enzyme Score Source PMID
S298 Phosphorylation HPRD 16964243
S300 Phosphorylation HPRD 18669648
S307 Phosphorylation HPRD 17322306, 18669648, 19664994, ...16964243
S385 Phosphorylation P15531 (NME1) HPRD 12105213


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 F22 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y26 H26 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S307 Y307 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S314 Y314 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S565 F565 Biomuta DOID:4159 / skin cancer [ cosmic ]