iPTMnet Report for Q969H0 (FBXW7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q969H0 / FBXW7_HUMAN
Protein Name F-box/WD repeat-containing protein 7
Gene Name Name: FBXW7
Synonyms:FBW7;
Organism Homo sapiens (Human)

PRO ID PR:Q969H0
DAG View
PRO Name F-box/WD repeat-containing protein 7 (human)
Definition An F-box/WD repeat-containing protein 7 that is encoded in the genome of human.
Short Label hFBXW7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q969H0 (FBXW7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation P17252 (PRKCA) , P41743 (PRKCI) PhosphoSitePlus 20815813
S18 Phosphorylation P41743 (PRKCI) , P17252 (PRKCA) PhosphoSitePlus   RLIMS-P 20815813, 28850619
S25 Phosphorylation Q9NYY3 (PLK2) PhosphoSitePlus   RLIMS-P 22399798, 31371703
S26 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30722038, 26774286, 17525332
S176 Phosphorylation Q9NYY3 (PLK2) PhosphoSitePlus   RLIMS-P   Signor 22399798, 31371703
S180 O-Glycosylation GlyGen 30379171
S182 O-Glycosylation GlyGen 30379171
T205 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus   RLIMS-P   UniProt 25753158, 22608923, 32457290
S227 Phosphorylation O00141 (SGK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 21147854
S349 Phosphorylation Q9NYY3 (PLK2) PhosphoSitePlus   RLIMS-P 22399798, 31371703
S372 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 27920218, 31371703
K404 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
C493 Methylation IEDB 31844290
C613 Methylation IEDB 31844290
S678 Phosphorylation PhosphoSitePlus
T680 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 17081983
S26 Phosphorylation HPRD 17525332


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P51532 (SMARCA4) S35 Q969H0 (FBXW7) unknown eFIP 30177679
Phosphorylation Q07820 (MCL1) S159 Q969H0 (FBXW7) increased_association eFIP 24261825
Phosphorylation Q07820 (MCL1) T163 Q969H0 (FBXW7) unknown eFIP 28404959
Phosphorylation Q9NRI5 (DISC1) T198 Q969H0 (FBXW7) unknown eFIP 28727686