iPTMnet Report for Q969F2 (NKD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q969F2 / NKD2_HUMAN
Protein Name Protein naked cuticle homolog 2
Gene Name Name: NKD2
Organism Homo sapiens (Human)

PRO ID PR:Q969F2
DAG View
PRO Name protein naked cuticle homolog 2 (human)
Definition A protein naked cuticle homolog 2 that is encoded in the genome of human.
Short Label hNKD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q969F2 (NKD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 15064403
S18 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
Y423 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S176 N176 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S223 T223 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T224 S224 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S230 L230 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T257 K257 Biomuta DOID:1324 / lung cancer [ cosmic ]
S333 F333 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]