Protein Information

Cytoscape View

UniProt AC / UniProt ID Q93077 / H2A1C_HUMAN
Protein Name Histone H2A type 1-C
Gene Name Name: H2AC6
Organism Homo sapiens (Human)

PRO ID PR:Q93077
DAG View
PRO Name histone H2A type 1-C (human)
Definition A histone H2A type 1-C that is encoded in the genome of human.
Short Label hH2AC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q93077 (H2AC6) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
S2 Acetylation UniProt 15823041, 16457589
S2 Phosphorylation PRO   PhosphoSitePlus   UniProt 15010469
K6 Acetylation PRO   PhosphoSitePlus 17709392
K6 Methylation PhosphoSitePlus
K10 Acetylation PRO   PhosphoSitePlus 18552846, 12937907
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S20 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
R30 Methylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
R82 Methylation PhosphoSitePlus
R89 Methylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
R100 Methylation PhosphoSitePlus
T102 Phosphorylation HPRD   PhosphoSitePlus 20068231
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
K120 Ubiquitination PRO   PhosphoSitePlus   UniProt 18400894, 25470042, 16359901, ...15386022, 16702407
T121 Phosphorylation HPRD   PRO   PhosphoSitePlus   UniProt 19965387, 24140421, 15078818, ...20068231
S123 Phosphorylation HPRD   PhosphoSitePlus 20068231
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044924 (hHIST1H2AC/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044925 (hHIST1H2AC/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000044926 (hHIST1H2AC/InitMet-/Phos:1) pS2 PRO 15010469
PR:000044928 (hHIST1H2AC/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000044933 (hHIST1H2AC/InitMet-/Phos:2) pT121 PRO 19965387
PR:000047722 (hHIST1H2AC/InitMet-/N6AcLys+) ac PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 P2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S20 F20 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R21 C21 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
R30 * Biomuta DOID:5041 / esophageal cancer [ tcga ]
Y40 N40 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R100 L100 Biomuta DOID:1324 / lung cancer [ tcga ]
R100 Q100 Biomuta DOID:1324 / lung cancer [ tcga ]
T102 I102 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Q105 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S123 T123 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K126 R126 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K126 E126 Biomuta DOID:0070003 / blastoma [ cosmic ]