iPTMnet Report for Q93077 (H2AC6)
Protein Information
| UniProt AC / UniProt ID | Q93077 / H2A1C_HUMAN |
| Protein Name | Histone H2A type 1-C |
| Gene Name | Name: H2AC6 Synonyms:H2AFL,HIST1H2AC; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q93077 |
| PRO Name | histone H2A type 1-C (human) |
| Definition | A histone H2A type 1-C that is encoded in the genome of human. |
| Short Label | hH2AC6 |
| Category | organism-gene |
DAG ViewQ93077 (H2AC6) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Acetylation | score1 | PRO | ||||
| S2 | Acetylation | score3 | UniProt | 15823041, 16457589 | ||
| S2 | Phosphorylation | score2 | PRO UniProt | 15010469 | ||
| K6 | Acetylation | score1 | PRO | 17709392 | ||
| K10 | Acetylation | score1 | PRO | 18552846, 12937907 | ||
| K14 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
| K16 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T102 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Q105 | Methylation | score1 | UniProt | 24352239 | ||
| K119 | Acetylation | score1 | PhosphoSitePlus | |||
| K119 | Sumoylation | score1 | PhosphoSitePlus | |||
| K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K120 | Ubiquitination | score2 | PRO UniProt | 18400894, 16359901, 15386022, ... | ||
| T121 | Phosphorylation | score2 | HPRD PRO UniProt | 19965387, 24140421, 15078818, ... | ||
| S123 | Phosphorylation | score0 | HPRD | 20068231 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000044924 (hHIST1H2AC/InitMet-/Ac:1) | acK6 | PRO | 17709392 | ||
| PR:000044925 (hHIST1H2AC/InitMet-/Ubiq:1) | ubK120 | PRO | 15386022, 18400894 | ||
| PR:000044926 (hHIST1H2AC/InitMet-/Phos:1) | pS2 | PRO | 15010469 | ||
| PR:000044928 (hHIST1H2AC/InitMet-/Ac:2) | acK10 | PRO | 12937907, 18552846 | ||
| PR:000044933 (hHIST1H2AC/InitMet-/Phos:2) | pT121 | PRO | 19965387 | ||
| PR:000047722 (hHIST1H2AC/InitMet-/N6AcLys+) | ac | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S2 | P2 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| T102 | I102 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| Q105 | H105 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Q105 | * | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| K120 | R120 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S123 | T123 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
