iPTMnet Report for Q93074 (MED12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q93074 / MED12_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 12
Gene Name Name: MED12
Synonyms:ARC240,CAGH45,HOPA,KIAA0192,TNRC11,TRAP230;
Organism Homo sapiens (Human)

PRO ID PR:Q93074
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 12 (human)
Definition A mediator of RNA polymerase II transcription subunit 12 that is encoded in the genome of human.
Short Label hMED12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q93074 (MED12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K32 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
T127 Phosphorylation IEDB 31848261
K132 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus   UniProt 18669648
T302 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
C481 Methylation IEDB 31844290
K515 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
C616 Methylation IEDB 31844290
S635 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19369195, 24275569, 19690332
S665 Phosphorylation PhosphoSitePlus   UniProt 24275569
S688 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S700 Phosphorylation PhosphoSitePlus   UniProt 23186163
K762 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
K780 Ubiquitination PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
C997 Methylation IEDB 31844290
K999 Acetylation PhosphoSitePlus
K999 Ubiquitination PhosphoSitePlus
K1001 Ubiquitination PhosphoSitePlus
K1181 Ubiquitination PhosphoSitePlus
K1194 Ubiquitination PhosphoSitePlus
S1258 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S1269 Phosphorylation PhosphoSitePlus   UniProt 19369195
K1298 Ubiquitination PhosphoSitePlus
K1414 Ubiquitination PhosphoSitePlus
K1434 Ubiquitination PhosphoSitePlus
K1445 Ubiquitination PhosphoSitePlus
K1453 Ubiquitination PhosphoSitePlus
K1471 Ubiquitination PhosphoSitePlus
K1524 Ubiquitination PhosphoSitePlus
K1534 Ubiquitination PhosphoSitePlus
T1593 Phosphorylation IEDB 32387766
K1619 Ubiquitination PhosphoSitePlus
K1622 Ubiquitination PhosphoSitePlus
K1634 Ubiquitination PhosphoSitePlus
K1643 Ubiquitination PhosphoSitePlus
K1661 Ubiquitination PhosphoSitePlus
K1664 Ubiquitination PhosphoSitePlus
K1673 Ubiquitination PhosphoSitePlus
K1674 Ubiquitination PhosphoSitePlus
K1682 Ubiquitination PhosphoSitePlus
K1761 Acetylation PhosphoSitePlus
K1761 Ubiquitination PhosphoSitePlus
S1778 Phosphorylation PhosphoSitePlus
T1779 Phosphorylation PhosphoSitePlus
K1788 Acetylation PhosphoSitePlus
K1790 Acetylation PhosphoSitePlus
K1791 Acetylation PhosphoSitePlus
K1798 Acetylation PhosphoSitePlus
K1798 Ubiquitination PhosphoSitePlus
S1838 Phosphorylation PhosphoSitePlus
R1854 Methylation PhosphoSitePlus
R1859 Methylation PhosphoSitePlus
R1862 Methylation PhosphoSitePlus
R1871 Methylation PhosphoSitePlus
R1899 Methylation PhosphoSitePlus
R1910 Methylation PhosphoSitePlus
R1912 Methylation PhosphoSitePlus
R1994 Methylation PhosphoSitePlus   UniProt 24129315
R2015 Methylation PhosphoSitePlus   UniProt 24129315
S2163 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y166 Phosphorylation HPRD 18669648
S635 Phosphorylation HPRD 18691976, 17081983, 18452278
S665 Phosphorylation HPRD 20068231
S698 Phosphorylation HPRD 19651622, 18691976, 18452278
S700 Phosphorylation HPRD 19651622, 18691976
S1258 Phosphorylation HPRD 18691976
S1269 Phosphorylation HPRD 18691976
S1778 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
R1912 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 T42 Biomuta DOID:1612 / breast cancer [ cosmic ]
K42 N42 Biomuta DOID:1612 / breast cancer [ cosmic ]
K68 N68 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T127 M127 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K132 N132 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K139 Q139 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S471 Y471 Biomuta DOID:1324 / lung cancer [ cosmic ]
S474 R474 Biomuta DOID:1324 / lung cancer [ cosmic ]
S476 Y476 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S479 F479 Biomuta DOID:4159 / skin cancer [ cosmic ]
K515 E515 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K515 T515 Biomuta DOID:4159 / skin cancer [ cosmic ]
K527 R527 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S700 F700 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1258 C1258 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1298 E1298 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1453 T1453 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1619 N1619 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
K1622 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1674 N1674 Biomuta DOID:363 / uterine cancer [ icgc ]
K1788 E1788 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1790 N1790 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1798 M1798 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R1859 H1859 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3953 / adrenal gland cancer [ cosmic ]
R1862 C1862 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R1862 L1862 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1899 W1899 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1899 Q1899 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
R1910 C1910 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1910 H1910 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1912 H1912 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
R1912 C1912 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R1994 L1994 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1994 W1994 Biomuta DOID:1319 / brain cancer [ cosmic ]
R2015 T2015 Biomuta DOID:1324 / lung cancer [ cosmic ]
R2015 M2015 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]