Protein Information

Cytoscape View

UniProt AC / UniProt ID Q93034 / CUL5_HUMAN
Protein Name Cullin-5
Gene Name Name: CUL5
Organism Homo sapiens (Human)

PRO ID PR:Q93034
DAG View
PRO Name cullin-5 (human)
Definition A cullin-5 that is encoded in the genome of human.
Short Label hCUL5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q93034 (CUL5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus   UniProt 23186163
T36 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
T210 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K237 Ubiquitination PhosphoSitePlus
K286 Acetylation PhosphoSitePlus
T346 Phosphorylation HPRD   PhosphoSitePlus 20068231
K356 Ubiquitination PhosphoSitePlus
Y373 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16497976
K384 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K447 Acetylation PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
S539 Phosphorylation HPRD   PhosphoSitePlus 19562805
K620 Ubiquitination PhosphoSitePlus
R631 Methylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
S730 Phosphorylation P17612 (PRKACA) HPRD   phospho.ELM   PhosphoSitePlus 19917606, 10898738
Y765 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 C34 Biomuta DOID:10534 / stomach cancer [ tcga ]
K74 E74 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K194 T194 Biomuta DOID:3070 / malignant glioma [ tcga ]
K286 R286 Biomuta DOID:1324 / lung cancer [ cosmic ]
S539 I539 Biomuta DOID:3571 / liver cancer [ icgc ]
R631 W631 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S656 L656 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]