iPTMnet Report for Q93009 (USP7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q93009 / UBP7_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 7
Gene Name Name: USP7
Synonyms:HAUSP;
Organism Homo sapiens (Human)

PRO ID PR:Q93009
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 7 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 7 that is encoded in the genome of human.
Short Label hUSP7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q93009 (USP7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26238070, 21406692, 23186163, ...22361354, 28418900, 15302935, 18669648, 24275569, 17651432, 20068231
S49 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
T74 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...34725712, 25367160, 35254053, 34019948, 35083852, 32119511
K98 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K209 Acetylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
R424 Methylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
C488 S-Nitrosylation dbSNO 26338901
K490 Ubiquitination PhosphoSitePlus
C510 S-Nitrosylation dbSNO 26338901
K523 Ubiquitination PhosphoSitePlus
K595 Acetylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
T730 Phosphorylation PhosphoSitePlus
Y735 Phosphorylation PhosphoSitePlus
K739 Sumoylation PhosphoSitePlus
T743 Phosphorylation PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
Y791 Phosphorylation PhosphoSitePlus
T802 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...34725712, 25367160, 35254053, 34019948, 35083852, 32119511
K824 Ubiquitination PhosphoSitePlus
K841 Acetylation PhosphoSitePlus
K841 Methylation PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus
Y845 Phosphorylation PhosphoSitePlus
K869 Acetylation PhosphoSitePlus   UniProt 19608861
K869 Sumoylation PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus   UniProt 17651432
K875 Ubiquitination PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
R891 Methylation PhosphoSitePlus
K914 Acetylation PhosphoSitePlus
K914 Ubiquitination PhosphoSitePlus
K926 Ubiquitination PhosphoSitePlus
K927 Ubiquitination PhosphoSitePlus
K934 Acetylation PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
S963 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 17651432
K1033 Ubiquitination PhosphoSitePlus
Y1050 Phosphorylation PhosphoSitePlus
Y1056 Phosphorylation PhosphoSitePlus
K1084 Acetylation PhosphoSitePlus   UniProt 19608861
K1084 Ubiquitination PhosphoSitePlus
Y1091 Phosphorylation PhosphoSitePlus
T1092 Phosphorylation PhosphoSitePlus
Y1093 Phosphorylation PhosphoSitePlus
K1096 Acetylation PhosphoSitePlus   UniProt 19608861
K1096 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 19413330, 20230923, 20058876, ...15302935, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231
S963 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8TB45 (DEPTOR) S235 Q93009 (USP7) unknown eFIP 35216969


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T54 I54 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K254 E254 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K479 N479 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K523 N523 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T730 S730 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y735 C735 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K875 N875 Biomuta DOID:1319 / brain cancer [ icgc ]
K934 I934 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S963 F963 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1050 C1050 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]