iPTMnet Report for Q93008 (USP9X)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q93008 / USP9X_HUMAN
Protein Name Probable ubiquitin carboxyl-terminal hydrolase FAF-X
Gene Name Name: USP9X
Synonyms:DFFRX,FAM,USP9;
Organism Homo sapiens (Human)

PRO ID PR:Q93008
DAG View
PRO Name probable ubiquitin carboxyl-terminal hydrolase FAF-X (human)
Definition A probable ubiquitin carboxyl-terminal hydrolase FAF-X that is encoded in the genome of human.
Short Label hUSP9X
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q93008 (USP9X) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K112 Ubiquitination PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K315 Acetylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
Y368 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
R560 Methylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus   UniProt 23186163
T590 Phosphorylation PhosphoSitePlus   UniProt 23186163
S593 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
Y701 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K794 Ubiquitination PhosphoSitePlus
Y797 Phosphorylation PhosphoSitePlus
R844 Methylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
Y868 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
T930 Phosphorylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
T984 Phosphorylation PhosphoSitePlus
K1045 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
Y1148 Phosphorylation PhosphoSitePlus
K1153 Ubiquitination PhosphoSitePlus
Y1232 Phosphorylation PhosphoSitePlus
K1370 Ubiquitination PhosphoSitePlus
Y1375 Phosphorylation PhosphoSitePlus
K1435 Ubiquitination PhosphoSitePlus
K1445 Ubiquitination PhosphoSitePlus
K1446 Ubiquitination PhosphoSitePlus
K1453 Ubiquitination PhosphoSitePlus
S1580 Phosphorylation PhosphoSitePlus
T1591 Phosphorylation PhosphoSitePlus
S1593 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1600 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18669648, 19690332
S1609 Phosphorylation PhosphoSitePlus
Y1620 Phosphorylation PhosphoSitePlus
K1627 Ubiquitination PhosphoSitePlus
K1632 Ubiquitination PhosphoSitePlus
K1637 Ubiquitination PhosphoSitePlus
K1669 Ubiquitination PhosphoSitePlus
K1712 Ubiquitination PhosphoSitePlus
K1722 Acetylation PhosphoSitePlus
K1722 Ubiquitination PhosphoSitePlus
K1773 Ubiquitination PhosphoSitePlus
K1798 Ubiquitination PhosphoSitePlus
K1811 Ubiquitination PhosphoSitePlus
Y1815 Phosphorylation PhosphoSitePlus
K1862 Ubiquitination PhosphoSitePlus
K1899 Ubiquitination PhosphoSitePlus
K1935 Ubiquitination PhosphoSitePlus
K2219 Ubiquitination PhosphoSitePlus
K2301 Ubiquitination PhosphoSitePlus
K2360 Ubiquitination PhosphoSitePlus
R2366 Methylation PhosphoSitePlus
T2438 Phosphorylation PhosphoSitePlus
Y2439 Phosphorylation PhosphoSitePlus
S2443 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17693683
S2448 Phosphorylation PhosphoSitePlus
S2462 Phosphorylation PhosphoSitePlus
S2502 Phosphorylation IEDB 32387766
Y2540 Phosphorylation PhosphoSitePlus   UniProt 15592455
S2543 Phosphorylation PhosphoSitePlus
S2547 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
T2551 Phosphorylation PhosphoSitePlus   UniProt 20068231
Site PTM Type PTM Enzyme Score Source PMID
S313 Phosphorylation HPRD 20068231
T590 Phosphorylation HPRD 18691976
Y701 Phosphorylation HPRD 20068231
S702 Phosphorylation HPRD 20068231
S1593 Phosphorylation HPRD 19651622, 18452278
S1600 Phosphorylation HPRD 18691976, 18767875, 18452278, ...19651622, 17322306, 18669648
S1609 Phosphorylation HPRD 18669648
Y2402 Phosphorylation HPRD 20068231
S2443 Phosphorylation HPRD 19651622, 18669648, 17081983, ...17693683
S2448 Phosphorylation HPRD 18691976
Y2540 Phosphorylation HPRD 15592455
S2547 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664994, 18452278, 18669648, 20068231
T2551 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S313 Phosphorylation HPRD 20068231
T590 Phosphorylation HPRD 18691976
Y701 Phosphorylation HPRD 20068231
S702 Phosphorylation HPRD 20068231
S1593 Phosphorylation HPRD 19651622, 18452278
S1600 Phosphorylation HPRD 18691976, 18767875, 18452278, ...19651622, 17322306, 18669648
S1609 Phosphorylation HPRD 18669648
Y2402 Phosphorylation HPRD 20068231
S2443 Phosphorylation HPRD 19651622, 18669648, 17081983, ...17693683
S2448 Phosphorylation HPRD 18691976
Y2556 Phosphorylation HPRD 15592455
S2563 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664994, 18452278, 18669648, 20068231
T2567 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K218 N218 Biomuta DOID:363 / uterine cancer [ icgc ]
S308 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S313 Y313 Biomuta DOID:363 / uterine cancer [ icgc ]
Y368 C368 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K441 R441 Biomuta DOID:4159 / skin cancer [ cosmic ]
K548 N548 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R560 H560 Biomuta DOID:1319 / brain cancer [ cosmic ]
S866 T866 Biomuta DOID:1612 / breast cancer [ cosmic ]
T930 I930 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1045 E1045 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1580 Y1580 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1798 T1798 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R2366 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2543 G2543 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
S2547 F2547 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2563 F2563 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]