iPTMnet Report for Q92995 (USP13)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92995 / UBP13_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 13
Gene Name Name: USP13
Synonyms:ISOT3;
Organism Homo sapiens (Human)

PRO ID PR:Q92995
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 13 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 13 that is encoded in the genome of human.
Short Label hUSP13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92995 (USP13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
R101 Methylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32772043, 19690332
T122 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
S128 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
T196 Phosphorylation RLIMS-P 28569838, 29396516
K210 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
T380 Phosphorylation PhosphoSitePlus   RLIMS-P 28569838
T385 Phosphorylation PhosphoSitePlus   RLIMS-P 28569838
T388 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K405 Sumoylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
C544 Methylation IEDB 31844290
K565 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
K640 Sumoylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
Y708 Phosphorylation PhosphoSitePlus   RLIMS-P 32453420
K830 Ubiquitination PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus
K850 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T122 Phosphorylation HPRD 18669648, 18452278
S228 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92995 (USP13) Y708 P01106 (MYC) unknown eFIP 32453420


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T122 N122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K176 N176 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T181 M181 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
K190 N190 Biomuta DOID:1324 / lung cancer [ cosmic ]
K210 M210 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K259 E259 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K339 N339 Biomuta DOID:263 / kidney cancer [ cosmic ]
T380 P380 Biomuta DOID:1319 / brain cancer [ cosmic ]
T385 I385 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T388 A388 Biomuta DOID:3571 / liver cancer [ cosmic ]
S396 L396 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K414 E414 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K598 T598 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K850 E850 Biomuta DOID:3571 / liver cancer [ cosmic ]