Protein Information

Cytoscape View

UniProt AC / UniProt ID Q92994 / TF3B_HUMAN
Protein Name Transcription factor IIIB 90 kDa subunit
Gene Name Name: BRF1
Organism Homo sapiens (Human)

PRO ID PR:Q92994
DAG View
PRO Name transcription factor IIIB 90 kDa subunit (human)
Definition A transcription factor IIIB 90 kDa subunit that is encoded in the genome of human.
Short Label hBRF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q92994 (BRF1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus   RLIMS-P 22281053
K304 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
T365 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S398 Phosphorylation PhosphoSitePlus
S433 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S436 Phosphorylation PhosphoSitePlus
S450 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 22281053
K494 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S553 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569
K590 Acetylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
T616 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T365 Phosphorylation HPRD 18669648
S433 Phosphorylation HPRD 17525332
S450 Phosphorylation HPRD 18669648
S547 Phosphorylation HPRD 17081983
S553 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
T161 Phosphorylation HPRD 18669648
S229 Phosphorylation HPRD 17525332
S246 Phosphorylation HPRD 18669648
S343 Phosphorylation HPRD 17081983
S349 Phosphorylation HPRD 17081983

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S226 * Biomuta DOID:3571 / liver cancer [ icgc ]
K254 T254 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S398 I398 Biomuta DOID:363 / uterine cancer [ tcga ]
S398 R398 Biomuta DOID:3571 / liver cancer [ icgc ]
S553 I553 Biomuta DOID:10283 / prostate cancer [ cosmic ]