iPTMnet Report for Q92993 (KAT5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92993 / KAT5_HUMAN
Protein Name Histone acetyltransferase KAT5
Gene Name Name: KAT5
Synonyms:HTATIP,TIP60;
Organism Homo sapiens (Human)

PRO ID PR:Q92993
DAG View
PRO Name histone acetyltransferase KAT5 (human)
Definition A histone acetyltransferase KAT5 that is encoded in the genome of human.
Short Label hKAT5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92993 (KAT5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K35 Ubiquitination PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus   UniProt 19608861
S86 Phosphorylation P49841 (GSK3B) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22539723, 23186163, 28032867, ...29335245, 21658600, 12468530, 16103124, 18669648, 30704899
S90 Phosphorylation P06493 (CDK1) , P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22539723, 23186163, 29335245, ...21658600, 12468530, 16103124, 26829474, 18669648
K104 Acetylation Q92993 (KAT5) PhosphoSitePlus   UniProt 25301942, 29174981
K120 Acetylation Q92993 (KAT5) PhosphoSitePlus   UniProt 25301942
K148 Acetylation Q92993 (KAT5) PhosphoSitePlus   UniProt 25301942
K150 Acetylation Q92993 (KAT5) PhosphoSitePlus   UniProt 25301942
S155 Phosphorylation PhosphoSitePlus
T158 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus   RLIMS-P 23685072, 36280132
K187 Acetylation Q92993 (KAT5) PhosphoSitePlus   UniProt 25301942
K189 Acetylation Q92993 (KAT5) PhosphoSitePlus   UniProt 25301942
S190 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 36280132
S202 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
K282 Acetylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
Y294 Phosphorylation P00519 (ABL1) PhosphoSitePlus 24044023
K296 Ubiquitination PhosphoSitePlus
T298 Phosphorylation Q02156 (PRKCE) neXtProt 17851107
S300 Phosphorylation Q02156 (PRKCE) neXtProt 17851107
K310 Ubiquitination PhosphoSitePlus
K327 Acetylation Q92993 (KAT5) PhosphoSitePlus   UniProt 24835996
C346 Methylation IEDB 31844290
Y376 Phosphorylation RLIMS-P 24044023
K404 Ubiquitination PhosphoSitePlus
K430 Sumoylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
K451 Sumoylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
Y472 Phosphorylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation P14635 (CCNB1) , P06493 (CDK1) HPRD 18669648, 12468530
S90 Phosphorylation P14635 (CCNB1) , P06493 (CDK1) HPRD 18669648, 12468530
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation P14635 (CCNB1) , P06493 (CDK1) HPRD   PhosphoSitePlus 18669648, 12468530
S90 Phosphorylation P14635 (CCNB1) , P06493 (CDK1) HPRD   PhosphoSitePlus 18669648, 12468530
S103 Phosphorylation PhosphoSitePlus
T106 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 23685072
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S119 O-Glycosylation PhosphoSitePlus
S119 Phosphorylation P14635 (CCNB1) , P06493 (CDK1) HPRD 18669648, 12468530
S123 Phosphorylation P14635 (CCNB1) , P06493 (CDK1) HPRD 18669648, 12468530


Q92993 (KAT5) as PTM Enzyme



Substrate Site Score Source PMID
Q92993 (KAT5) K104 UniProt 25301942
Q92993 (KAT5) K120 UniProt 25301942
Q92993 (KAT5) K148 UniProt 25301942
Q92993 (KAT5) K150 UniProt 25301942
Q92993 (KAT5) K187 UniProt 25301942
Q92993 (KAT5) K189 UniProt 25301942
Q92993 (KAT5) K327 UniProt 24835996


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92993 (KAT5) Y376 O00213 (APBB1) unknown eFIP 24044023


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K35 E35 Biomuta DOID:4159 / skin cancer [ cosmic ]
K35 R35 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S103 L103 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S155 L155 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S190 L190 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
K274 N274 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K282 T282 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S300 F300 Biomuta [ cosmic ]
K310 N310 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
S431 L431 Biomuta DOID:363 / uterine cancer [ icgc ]
Y472 C472 Biomuta DOID:9256 / colorectal cancer [ cosmic ]