Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92985 / IRF7_HUMAN
Protein Name Interferon regulatory factor 7
Gene Name Name: IRF7
Organism Homo sapiens (Human)

PRO ID PR:Q92985
DAG View
PRO Name interferon regulatory factor 7 (human)
Definition An interferon regulatory factor 7 that is encoded in the genome of human.
Short Label hIRF7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92985 (IRF7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K50 Ubiquitination PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus   UniProt 12374802
K92 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S471 Phosphorylation Q9UHD2 (TBK1) , Q14164 (IKBKE) PhosphoSitePlus   Signor 10893229, 16914100
S472 Phosphorylation Q9UHD2 (TBK1) , Q14164 (IKBKE) PhosphoSitePlus   Signor 10893229, 16914100
S477 Phosphorylation Q14164 (IKBKE) , Q9UHD2 (TBK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 22787218, 16914100, 15367631, ...28367002, 28768858
S479 Phosphorylation Q14164 (IKBKE) , Q9UHD2 (TBK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 22787218, 15367631, 28367002, ...16914100
S483 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S477 Phosphorylation PRO 10893229, 14517278
S479 Phosphorylation PRO 10893229, 14517278
Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048049 (hIRF7/Phos:1) pS477,pS479 PRO
PR:000048050 (hIRF7/UbiqLys+) ub PRO
PR:000027082 (hIRF7/iso:1/Phos:1) pS477,pS479 PRO 10893229, 14517278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K452 N452 Biomuta DOID:3070 / malignant glioma [ tcga ]
S479 R479 Biomuta DOID:363 / uterine cancer [ tcga ]
S483 C483 Biomuta DOID:4362 / cervical cancer [ tcga ]
S487 N487 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]