iPTMnet Report for Q92974 (ARHGEF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92974 / ARHG2_HUMAN
Protein Name Rho guanine nucleotide exchange factor 2
Gene Name Name: ARHGEF2
Synonyms:KIAA0651,LFP40;
Organism Homo sapiens (Human)

PRO ID PR:Q92974
DAG View
PRO Name Rho guanine nucleotide exchange factor 2 (human)
Definition A Rho guanine nucleotide exchange factor 2 that is encoded in the genome of human.
Short Label hARHGEF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92974 (ARHGEF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K100 Methylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus   UniProt 23186163
T115 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y125 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus   UniProt 23186163
S133 Phosphorylation PhosphoSitePlus   UniProt 23186163
S137 Phosphorylation PhosphoSitePlus   UniProt 23186163
S142 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 21513698, 15827085
S143 Phosphorylation Q7KZI7 (MARK2) PhosphoSitePlus 21513698
S145 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S149 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S151 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18220336, 23186163, 29089450
T152 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T153 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S163 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220, 23186163, ...18220336
S172 Phosphorylation PhosphoSitePlus   UniProt 21513698, 21851590, 23186163, ...19690332
S172 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S172 Phosphorylation Q7KZI7 (MARK2) PhosphoSitePlus 21513698
S174 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 25418920
T175 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus   UniProt 23186163
T184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus 21513698
S186 Phosphorylation Q7KZI7 (MARK2) PhosphoSitePlus 21513698
S189 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S330 Phosphorylation RLIMS-P 23816534
K336 Ubiquitination PhosphoSitePlus
C342 Methylation IEDB 31844290
K347 Ubiquitination PhosphoSitePlus
K353 Acetylation PhosphoSitePlus   UniProt 19608861
K353 Ubiquitination PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
K376 Methylation PhosphoSitePlus
C383 S-Nitrosylation dbSNO 26338901
T392 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K482 Acetylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 33500736
S648 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18669648, 33500736
K666 Ubiquitination PhosphoSitePlus
T679 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18211802, 19690332, 24275569, ...19261619
T679 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 18211802, 19261619
T679 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 19261619, 18211802
S691 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33500736, 19690332
T695 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus   UniProt 18669648, 16964243, 19690332
S711 Phosphorylation PhosphoSitePlus   UniProt 23186163
C715 S-Nitrosylation dbSNO 26338901
S719 Phosphorylation PhosphoSitePlus
S721 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
K799 Acetylation PhosphoSitePlus
K799 Ubiquitination PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
T830 Phosphorylation PhosphoSitePlus
S886 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 32692911, 28096473, ...18669648, 22072711, 17488622, 15827085, 14970201, 19667072, 19690332, 20406887
S886 Phosphorylation O14965 (AURKA) neXtProt 17488622
S886 Phosphorylation O96013 (PAK4) neXtProt 15827085, 20406887
S886 Phosphorylation Q13153 (PAK1) neXtProt   PhosphoSitePlus   Signor 14970201, 19667072
S886 Phosphorylation Q16512 (PKN1) Signor 14970201
S886 Phosphorylation Q7KZI7 (MARK2) neXtProt   Signor 22072711
Y894 Phosphorylation PhosphoSitePlus   UniProt 18669648
S896 Phosphorylation PhosphoSitePlus   UniProt 15827085
S903 Phosphorylation PhosphoSitePlus
R904 Methylation PhosphoSitePlus
T914 O-Glycosylation GlyGen 23301498, 30379171, 28411811, ...28510447, 28657654
S932 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 33500736
S940 Phosphorylation PhosphoSitePlus   UniProt 18669648
S941 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332
T945 Phosphorylation PhosphoSitePlus   UniProt 19690332
S947 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33500736, 19690332
S952 Phosphorylation PhosphoSitePlus   RLIMS-P 33500736
S953 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33500736, 19690332
S956 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 33500736, ...18669648, 24275569, 19690332
S960 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 33500736, ...18669648, 22072711, 17488622, 19690332
S960 Phosphorylation Q7KZI7 (MARK2) neXtProt   Signor 22072711
S976 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation HPRD 19691289
S163 Phosphorylation HPRD 18669648, 16565220
S172 Phosphorylation HPRD 18077418
S174 Phosphorylation HPRD 19413330, 20058876, 18767875, ...18077418, 19664994, 19691289, 18669648, 18707149, 19415658
T175 Phosphorylation HPRD 18077418, 20058876
S177 Phosphorylation HPRD 19413330, 19691289
S645 Phosphorylation HPRD 18088087, 19691289, 19007248, ...19651622, 18669648, 18707149
S648 Phosphorylation HPRD 18669648
T679 Phosphorylation HPRD 18707149
S691 Phosphorylation HPRD 19651622, 18707149
T695 Phosphorylation HPRD 18669648, 19415658, 20068231
S696 Phosphorylation HPRD 19413330, 16964243, 19691289, ...16565220, 19651622, 18669648, 19415658, 20068231
T700 Phosphorylation HPRD 17081983
S782 Phosphorylation HPRD 19413330
T802 Phosphorylation HPRD 20068230
S886 Phosphorylation HPRD 14970201, 18669648
S886 Phosphorylation Q13153 (PAK1) HPRD 14970201, 18669648
Y894 Phosphorylation HPRD 15592455, 18669648, 18707149
S932 Phosphorylation HPRD 15302935, 19691289, 19651622, ...18669648, 18707149, 20068231
S940 Phosphorylation HPRD 18669648, 20068231
S941 Phosphorylation HPRD 18669648, 16964243, 18452278
S953 Phosphorylation HPRD 18669648
S956 Phosphorylation HPRD 18669648, 20068231
S960 Phosphorylation HPRD 18669648
S976 Phosphorylation HPRD 19691289
Site PTM Type PTM Enzyme Score Source PMID
T184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
T678 Phosphorylation PhosphoSitePlus 24043311
T678 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 24043311
S695 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus 22072711, 20406887
S885 Phosphorylation O96013 (PAK4) PhosphoSitePlus 20406887
S885 Phosphorylation Q7KZI7 (MARK2) PhosphoSitePlus 22072711
S959 Phosphorylation neXtProt   PhosphoSitePlus 22072711, 17488622, 24043311
S959 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 24043311
S959 Phosphorylation Q7KZI7 (MARK2) PhosphoSitePlus 22072711
Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation HPRD 19691289
S136 Phosphorylation HPRD 18669648, 16565220
S145 Phosphorylation HPRD 18077418
S147 Phosphorylation HPRD 19413330, 20058876, 18767875, ...18077418, 19664994, 19691289, 18669648, 18707149, 19415658
T148 Phosphorylation HPRD 18077418, 20058876
S150 Phosphorylation HPRD 19413330, 19691289
S617 Phosphorylation HPRD 18088087, 19691289, 19007248, ...19651622, 18669648, 18707149
S620 Phosphorylation HPRD 18669648
T651 Phosphorylation HPRD 18707149
S663 Phosphorylation HPRD 19651622, 18707149
T667 Phosphorylation HPRD 18669648, 19415658, 20068231
S668 Phosphorylation HPRD 19413330, 16964243, 19691289, ...16565220, 19651622, 18669648, 19415658, 20068231
T672 Phosphorylation HPRD 17081983
S754 Phosphorylation HPRD 19413330
T774 Phosphorylation HPRD 20068230
S858 Phosphorylation HPRD 14970201, 18669648
S858 Phosphorylation Q13153 (PAK1) HPRD 14970201, 18669648
Y866 Phosphorylation HPRD 15592455, 18669648, 18707149
S904 Phosphorylation HPRD 15302935, 19691289, 19651622, ...18669648, 18707149, 20068231
S912 Phosphorylation HPRD 18669648, 20068231
S913 Phosphorylation HPRD 18669648, 16964243, 18452278
S925 Phosphorylation HPRD 18669648
S928 Phosphorylation HPRD 18669648, 20068231
S932 Phosphorylation HPRD 18669648
S948 Phosphorylation HPRD 19691289


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 F6 Biomuta DOID:4159 / skin cancer [ cosmic ]
K100 M100 Biomuta DOID:3571 / liver cancer [ cosmic ]
S122 L122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y125 S125 Biomuta DOID:4159 / skin cancer [ cosmic ]
S133 F133 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S137 F137 Biomuta DOID:1612 / breast cancer [ cosmic ]
S147 F147 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S147 P147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T148 K148 Biomuta DOID:3571 / liver cancer [ cosmic ]
S174 F174 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S174 P174 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T175 K175 Biomuta DOID:3571 / liver cancer [ cosmic ]
T184 I184 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S186 F186 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y198 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K230 T230 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K255 R255 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C342 S342 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C342 Y342 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S522 L522 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K600 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S617 F617 Biomuta [ cosmic ]
S643 F643 Biomuta DOID:4159 / skin cancer [ cosmic ]
S645 F645 Biomuta [ cosmic ]
T667 M667 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T695 M695 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S721 C721 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S896 R896 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R904 Q904 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T914 I914 Biomuta [ cosmic ]
S925 R925 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S932 N932 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S952 T952 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S953 R953 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S959 N959 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S960 N960 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic ]