iPTMnet Report for Q92973 (TNPO1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92973 / TNPO1_HUMAN
Protein Name Transportin-1
Gene Name Name: TNPO1
Synonyms:KPNB2,MIP1,TRN;
Organism Homo sapiens (Human)

PRO ID PR:Q92973
DAG View
PRO Name transportin-1 (human)
Definition A transportin-1 that is encoded in the genome of human.
Short Label hTNPO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92973 (TNPO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895
T7 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 26853435, 34019948, 35083852, 32119511, 22121020, 33465208
S30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
C205 Methylation IEDB 31844290
K307 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
C520 Methylation IEDB 31844290
Y569 Phosphorylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
C713 Methylation IEDB 31844290
K818 Ubiquitination PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation HPRD 20068231
S32 Phosphorylation HPRD 18691976, 20068231
T35 Phosphorylation HPRD 20068231
T36 Phosphorylation HPRD 20068231
T782 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 20068231
S24 Phosphorylation HPRD 18691976, 20068231
T27 Phosphorylation HPRD 20068231
T28 Phosphorylation HPRD 20068231
T774 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8IYT8 (ULK2) S1027 Q92973 (TNPO1) unknown eFIP 26052940


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S74 L74 Biomuta DOID:4159 / skin cancer [ cosmic ]
K81 N81 Biomuta DOID:1324 / lung cancer [ cosmic ]
K192 M192 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K192 R192 Biomuta DOID:4159 / skin cancer [ cosmic ]
K327 M327 Biomuta DOID:4159 / skin cancer [ cosmic ]
T352 M352 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y569 C569 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]