iPTMnet Report for Q92954 (PRG4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92954 / PRG4_HUMAN
Protein Name Proteoglycan 4 precursor
Gene Name Name: PRG4
Synonyms:MSF,SZP;
Organism Homo sapiens (Human)

PRO ID PR:Q92954
DAG View
PRO Name proteoglycan 4 (human)
Definition A proteoglycan 4 that is encoded in the genome of human.
Short Label hPRG4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92954 (PRG4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S123 O-Glycosylation GlyGen   UniProt 25187573
S136 O-Glycosylation GlyGen   UniProt 25187573
S136 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
T213 O-Glycosylation GlyGen 30459171
T234 O-Glycosylation GlyGen 30459171
T235 O-Glycosylation GlyGen 30459171
T240 O-Glycosylation GlyGen   UniProt 25187573
T253 O-Glycosylation GlyGen   UniProt 25187573
T254 O-Glycosylation GlyGen 30459171
S263 O-Glycosylation GlyGen 30459171
T277 O-Glycosylation GlyGen   UniProt 25187573
T282 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
T291 O-Glycosylation GlyGen   UniProt 25187573
T305 O-Glycosylation GlyGen   UniProt 25187573
S306 O-Glycosylation GlyGen   UniProt 25187573
T310 O-Glycosylation GlyGen   UniProt 25187573
S317 O-Glycosylation GlyGen   UniProt 25187573
T324 O-Glycosylation GlyGen   UniProt 25187573
T332 O-Glycosylation GlyGen   UniProt 25187573
T338 O-Glycosylation GlyGen   UniProt 25187573
T345 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
T367 O-Glycosylation GlyGen   UniProt 25187573
T369 Phosphorylation PhosphoSitePlus
S373 O-Glycosylation GlyGen   UniProt 25187573
S373 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T376 O-Glycosylation GlyGen   UniProt 25187573
T377 Phosphorylation PhosphoSitePlus
T384 O-Glycosylation GlyGen   UniProt 25187573
T384 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
T385 O-Glycosylation GlyGen   UniProt 25187573
T386 Phosphorylation PhosphoSitePlus
S388 O-Glycosylation GlyGen   UniProt 25187573
S388 Phosphorylation PhosphoSitePlus
T391 O-Glycosylation GlyGen   UniProt 25187573
T399 O-Glycosylation GlyGen   UniProt 25187573
T400 O-Glycosylation GlyGen   UniProt 25187573
T407 O-Glycosylation GlyGen   UniProt 25187573
T408 O-Glycosylation GlyGen   UniProt 25187573
T415 O-Glycosylation GlyGen   UniProt 25187573
T423 O-Glycosylation GlyGen   UniProt 25187573
S427 O-Glycosylation GlyGen   UniProt 25187573
S427 Phosphorylation PhosphoSitePlus
T430 O-Glycosylation GlyGen   UniProt 25187573
T430 Phosphorylation PhosphoSitePlus
T438 O-Glycosylation GlyGen   UniProt 25187573
T438 Phosphorylation PhosphoSitePlus
T439 O-Glycosylation GlyGen   UniProt 25187573
T439 Phosphorylation PhosphoSitePlus
T446 O-Glycosylation GlyGen   UniProt 25187573
T447 O-Glycosylation GlyGen   UniProt 25187573
T454 O-Glycosylation GlyGen   UniProt 25187573
T455 O-Glycosylation GlyGen   UniProt 25187573
T462 Phosphorylation PhosphoSitePlus
T477 O-Glycosylation GlyGen   UniProt 25187573
T478 O-Glycosylation GlyGen   UniProt 25187573
T485 O-Glycosylation GlyGen   UniProt 25187573
T493 O-Glycosylation GlyGen   UniProt 25187573
T493 Phosphorylation PhosphoSitePlus
T494 O-Glycosylation GlyGen   UniProt 25187573
T501 O-Glycosylation GlyGen   UniProt 25187573
T501 Phosphorylation PhosphoSitePlus
T502 O-Glycosylation GlyGen   UniProt 25187573
K504 Acetylation PhosphoSitePlus
T509 O-Glycosylation GlyGen   UniProt 25187573
T511 Phosphorylation PhosphoSitePlus
K512 Acetylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
T525 O-Glycosylation GlyGen   UniProt 25187573
S529 O-Glycosylation GlyGen   UniProt 25187573
T532 O-Glycosylation GlyGen   UniProt 25187573
T540 O-Glycosylation GlyGen   UniProt 25187573
T541 O-Glycosylation GlyGen   UniProt 25187573
S544 Phosphorylation PhosphoSitePlus
S553 O-Glycosylation GlyGen   UniProt 25187573
T555 O-Glycosylation GlyGen   UniProt 25187573
T563 O-Glycosylation GlyGen   UniProt 25187573
T564 O-Glycosylation GlyGen   UniProt 25187573
T571 O-Glycosylation GlyGen   UniProt 25187573
T572 O-Glycosylation GlyGen   UniProt 25187573
T579 O-Glycosylation GlyGen   UniProt 25187573
T580 O-Glycosylation GlyGen   UniProt 25187573
T580 Phosphorylation PhosphoSitePlus
T587 O-Glycosylation GlyGen   UniProt 25187573
T588 O-Glycosylation GlyGen   UniProt 25187573
K590 Acetylation PhosphoSitePlus
T595 O-Glycosylation GlyGen   UniProt 25187573
T597 Phosphorylation PhosphoSitePlus
K598 Acetylation PhosphoSitePlus
T603 O-Glycosylation GlyGen   UniProt 25187573
T604 O-Glycosylation GlyGen   UniProt 25187573
T611 O-Glycosylation GlyGen   UniProt 25187573
T612 O-Glycosylation GlyGen   UniProt 25187573
T612 Phosphorylation PhosphoSitePlus
T616 O-Glycosylation GlyGen   UniProt 25187573
T619 O-Glycosylation GlyGen   UniProt 25187573
T625 Phosphorylation PhosphoSitePlus
T627 O-Glycosylation GlyGen   UniProt 25187573
T628 Phosphorylation PhosphoSitePlus
T635 O-Glycosylation GlyGen 30459171
T651 Phosphorylation PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
T660 Phosphorylation PhosphoSitePlus
T676 O-Glycosylation GlyGen   UniProt 25187573
T683 O-Glycosylation GlyGen   UniProt 25187573
T684 O-Glycosylation GlyGen   UniProt 25187573
T691 O-Glycosylation GlyGen   UniProt 25187573
T692 O-Glycosylation GlyGen   UniProt 25187573
T699 O-Glycosylation GlyGen   UniProt 25187573
T700 O-Glycosylation GlyGen   UniProt 25187573
T704 O-Glycosylation GlyGen   UniProt 25187573
T707 O-Glycosylation GlyGen   UniProt 25187573
T723 O-Glycosylation GlyGen   UniProt 25187573
T724 O-Glycosylation GlyGen   UniProt 25187573
T736 O-Glycosylation GlyGen   UniProt 25187573
T752 Phosphorylation PhosphoSitePlus
T753 Phosphorylation PhosphoSitePlus
T757 Phosphorylation PhosphoSitePlus
T760 Phosphorylation PhosphoSitePlus
T761 Phosphorylation PhosphoSitePlus
T768 O-Glycosylation GlyGen   UniProt 25187573
T769 O-Glycosylation GlyGen   UniProt 25187573
T776 O-Glycosylation GlyGen   UniProt 25187573
T777 O-Glycosylation GlyGen   UniProt 25187573
T781 O-Glycosylation GlyGen 30459171
T792 O-Glycosylation GlyGen   UniProt 25187573
T793 O-Glycosylation GlyGen   UniProt 25187573
T805 O-Glycosylation GlyGen   UniProt 25187573
T806 Phosphorylation PhosphoSitePlus
S812 O-Glycosylation GlyGen   UniProt 25187573
T813 O-Glycosylation GlyGen 30459171
T814 Phosphorylation PhosphoSitePlus
S815 O-Glycosylation GlyGen 30459171
S815 Phosphorylation PhosphoSitePlus
T822 O-Glycosylation GlyGen 30459171
T829 O-Glycosylation GlyGen   UniProt 25187573
T830 O-Glycosylation GlyGen 30459171
K832 Ubiquitination PhosphoSitePlus
T837 O-Glycosylation GlyGen   UniProt 25187573
T838 O-Glycosylation GlyGen   UniProt 25187573
K841 Ubiquitination PhosphoSitePlus
T846 Phosphorylation PhosphoSitePlus
T853 Phosphorylation PhosphoSitePlus
T859 Phosphorylation PhosphoSitePlus
T863 O-Glycosylation GlyGen 30459171
T867 Phosphorylation PhosphoSitePlus
T868 Phosphorylation PhosphoSitePlus
S892 O-Glycosylation GlyGen   UniProt 25187573
T900 O-Glycosylation GlyGen   UniProt 25187573
T903 O-Glycosylation GlyGen 30459171
T903 Phosphorylation PhosphoSitePlus
T930 O-Glycosylation GlyGen   UniProt 25187573
T931 O-Glycosylation GlyGen   UniProt 25187573
T932 Phosphorylation PhosphoSitePlus
T938 Phosphorylation PhosphoSitePlus
K939 Acetylation PhosphoSitePlus
T941 Phosphorylation PhosphoSitePlus
K947 Acetylation PhosphoSitePlus
T948 Phosphorylation PhosphoSitePlus
T954 Phosphorylation PhosphoSitePlus
T956 Phosphorylation PhosphoSitePlus
T958 Phosphorylation PhosphoSitePlus
S962 O-Glycosylation GlyGen   UniProt 25187573
S962 Phosphorylation PhosphoSitePlus
T963 O-Glycosylation GlyGen   UniProt 25187573
T968 O-Glycosylation GlyGen   UniProt 25187573
T975 O-Glycosylation GlyGen   UniProt 25187573
T978 O-Glycosylation GlyGen   UniProt 25187573
T978 Phosphorylation PhosphoSitePlus
T979 O-Glycosylation GlyGen   UniProt 25187573
T980 O-Glycosylation GlyGen   UniProt 25187573
T994 O-Glycosylation GlyGen 30459171
T995 O-Glycosylation GlyGen 30459171
T1039 O-Glycosylation GlyGen   UniProt 25187573
T1076 O-Glycosylation GlyGen 30459171
S1094 Phosphorylation PhosphoSitePlus
N1159 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 24190977, ...29741879
T1161 O-Glycosylation GlyGen   UniProt 25187573
K1280 Ubiquitination PhosphoSitePlus
Y1365 Phosphorylation PhosphoSitePlus
S1397 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y9 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S123 P123 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S123 L123 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T234 I234 Biomuta DOID:10283 / prostate cancer [ icgc ]
T305 A305 Biomuta DOID:363 / uterine cancer [ icgc ]
S373 A373 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S388 T388 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T407 N407 Biomuta DOID:1324 / lung cancer [ cosmic ]
S427 P427 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ icgc ]
S427 Y427 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S427 A427 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T439 A439 Biomuta DOID:1324 / lung cancer [ cosmic ]
T493 P493 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K504 N504 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K504 E504 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T511 P511 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T511 A511 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K512 N512 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T518 P518 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S529 T529 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S529 A529 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T532 S532 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T532 P532 Biomuta DOID:1324 / lung cancer [ cosmic ]
T541 P541 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S544 P544 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S553 A553 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T555 I555 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T564 A564 Biomuta DOID:263 / kidney cancer [ cosmic ]
T572 A572 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T597 P597 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T603 P603 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T604 A604 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
T604 P604 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T625 M625 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T635 I635 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T660 I660 Biomuta DOID:4159 / skin cancer [ cosmic ]
T660 S660 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T704 P704 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T723 P723 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T724 P724 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T724 S724 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T752 I752 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T757 P757 Biomuta DOID:3571 / liver cancer [ cosmic ]
T781 P781 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ]
T781 I781 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S812 F812 Biomuta DOID:1324 / lung cancer [ cosmic ]
S812 Y812 Biomuta DOID:1324 / lung cancer [ cosmic ]
T814 S814 Biomuta DOID:1324 / lung cancer [ cosmic ]
K841 R841 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T930 A930 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T932 I932 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T975 A975 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T978 I978 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K1280 R1280 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]