iPTMnet Report for Q92905 (COPS5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92905 / CSN5_HUMAN
Protein Name COP9 signalosome complex subunit 5
Gene Name Name: COPS5
Synonyms:CSN5,JAB1;
Organism Homo sapiens (Human)

PRO ID PR:Q92905
DAG View
PRO Name COP9 signalosome complex subunit 5 (human)
Definition A COP9 signalosome complex subunit 5 that is encoded in the genome of human.
Short Label hCOPS5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92905 (COPS5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 18850735
S4 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K47 Acetylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation HPRD 18669648
K125 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus   RLIMS-P 34244488
K180 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
Y261 Phosphorylation HPRD 20068231
S276 Phosphorylation PhosphoSitePlus
R282 Methylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
R294 Methylation PhosphoSitePlus
K295 Methylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H3M7 (TXNIP) S361 Q92905 (COPS5) unknown eFIP 30410860


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 L71 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K191 R191 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y203 H203 Biomuta DOID:4159 / skin cancer [ cosmic ]
T205 I205 Biomuta DOID:4159 / skin cancer [ cosmic ]
S276 T276 Biomuta DOID:1324 / lung cancer [ cosmic ]
R282 Q282 Biomuta DOID:4159 / skin cancer [ cosmic ]
T291 M291 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R294 Q294 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]