Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92900 / RENT1_HUMAN
Protein Name Regulator of nonsense transcripts 1
Gene Name Name: UPF1
Synonyms:KIAA0221,RENT1;
Organism Homo sapiens (Human)

PRO ID PR:Q92900
DAG View
PRO Name regulator of nonsense transcripts 1 (human)
Definition A regulator of nonsense transcripts 1 that is encoded in the genome of human.
Short Label hUPF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92900 (UPF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus   UniProt 24275569
T28 Phosphorylation Q96Q15 (SMG1) PhosphoSitePlus   RLIMS-P   Signor 23275559, 21965535, 23356578, ...26130714, 25053839
S31 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y113 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
R433 Methylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus
Y488 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus   UniProt 23186163
K587 Ubiquitination PhosphoSitePlus
K592 Acetylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K786 Acetylation PhosphoSitePlus
K786 Ubiquitination PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
R811 Methylation PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
Y879 Phosphorylation PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
K926 Ubiquitination PhosphoSitePlus
K929 Ubiquitination PhosphoSitePlus
R939 Methylation PhosphoSitePlus
Y946 Phosphorylation PhosphoSitePlus
S956 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y958 Phosphorylation PhosphoSitePlus
Y970 Phosphorylation PhosphoSitePlus
R1019 Methylation PhosphoSitePlus   UniProt 24129315
S1084 Phosphorylation Q96Q15 (SMG1) PRO   PhosphoSitePlus 11544179
S1089 Phosphorylation Q96Q15 (SMG1) PRO   PhosphoSitePlus   Signor   UniProt 16452507, 23356578, 11544179
S1100 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation Q96Q15 (SMG1) phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 17525332, 23186163, 17081983, ...16452507, 23356578, 21406692, 21965535, 18669648, 11544179, 19690332, 20068231
S1110 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 20068231, ...17081983
T1111 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1112 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1118 Phosphorylation PhosphoSitePlus
S1127 Phosphorylation Q96Q15 (SMG1) phospho.ELM   PRO   PhosphoSitePlus   UniProt 17525332, 18220336, 18669648, ...11544179, 20068231
Y1129 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
Site PTM Type PTM Enzyme Score Source PMID
S215 Phosphorylation HPRD 20068231
Y344 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
R355 Methylation PhosphoSitePlus
T464 Phosphorylation HPRD 20068231
S474 Phosphorylation HPRD 20068231
S557 Phosphorylation HPRD 20068231
S1096 Phosphorylation HPRD 19413330, 17525332, 18767875, ...18077418, 19664994, 19664995, 19651622, 18669648, 19415658, 20068231
S1099 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19415658
T1100 Phosphorylation HPRD 18669648, 17081983, 20068231
Y1101 Phosphorylation HPRD 18669648, 20068231
T1113 Phosphorylation HPRD 20068231
S1116 Phosphorylation HPRD   PhosphoSitePlus 17525332, 18077418, 19664994, ...19664995, 18669648, 19415658, 20068231
Y1118 Phosphorylation HPRD 19415658


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049622 (hUPF1/Phos:1) pS1084,pS1089,pS1107,pS1127 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92900 (UPF1) T28 Q86US8 (SMG6) unknown eFIP 21965535
Phosphorylation Q92900 (UPF1) T28 Q86US8 (SMG6) unknown eFIP 25013172


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q92900-2 (hUPF1/iso:2) Interaction PR:Q14152 (hEIF3A) PRO 18423202
PR:Q92900-2 (hUPF1/iso:2) Interaction PR:Q14152 (hEIF3A) PRO 18423202
PR:Q92900-2 (hUPF1/iso:2) Interaction PR:Q14152 (hEIF3A) PRO 18423202