Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92890 / UFD1_HUMAN
Protein Name Ubiquitin recognition factor in ER-associated degradation protein 1
Gene Name Name: UFD1
Synonyms:UFD1L;
Organism Homo sapiens (Human)

PRO ID PR:Q92890
DAG View
PRO Name ubiquitin recognition factor in ER-associated degradation protein 1 (human)
Definition A ubiquitin recognition factor in ER-associated degradation protein 1 that is encoded in the genome of human.
Short Label hUFD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92890 (UFD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S3 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus   UniProt 23186163
T136 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
R170 Methylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K238 Acetylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S247 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
K302 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T210 Phosphorylation HPRD 20068231
S231 Phosphorylation HPRD 20068231
S245 Phosphorylation HPRD 19651622, 18669648, 20068231
S247 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231, 17924679
S299 Phosphorylation HPRD 18491316, 17287340, 18767875, ...19664994, 19664995, 18669648, 20166139, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T210 Phosphorylation HPRD 20068231
S231 Phosphorylation HPRD 20068231
S245 Phosphorylation HPRD 19651622, 18669648, 20068231
S247 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231, 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 Y3 Biomuta DOID:1612 / breast cancer [ cosmic ]
S29 F29 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K124 R124 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K124 T124 Biomuta DOID:363 / uterine cancer [ tcga ]
T136 A136 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T136 N136 Biomuta DOID:3571 / liver cancer [ icgc ]
K165 N165 Biomuta DOID:3070 / malignant glioma [ tcga ]
K255 E255 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
Y261 C261 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K280 E280 Biomuta DOID:1324 / lung cancer [ cosmic ]