iPTMnet Report for Q92889 (ERCC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92889 / XPF_HUMAN
Protein Name DNA repair endonuclease XPF
Gene Name Name: ERCC4
Synonyms:ERCC11,XPF;
Organism Homo sapiens (Human)

PRO ID PR:Q92889
DAG View
PRO Name DNA repair endonuclease XPF (human)
Definition A DNA repair endonuclease XPF that is encoded in the genome of human.
Short Label hERCC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92889 (ERCC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y191 Phosphorylation PhosphoSitePlus
K260 Acetylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K289 Acetylation PhosphoSitePlus   UniProt 19608861
K371 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
K500 Acetylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
T660 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
T710 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
K911 Acetylation PhosphoSitePlus   UniProt 32034146
Site PTM Type PTM Enzyme Score Source PMID
S520 Phosphorylation HPRD 17081983
S521 Phosphorylation HPRD 17081983
S524 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y191 C191 Biomuta DOID:263 / kidney cancer [ cosmic ]
K264 N264 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S520 N520 Biomuta DOID:4159 / skin cancer [ cosmic ]
S521 R521 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S524 N524 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S662 P662 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K753 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K911 I911 Biomuta [ cosmic ]