iPTMnet Report for Q92888 (ARHGEF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92888 / ARHG1_HUMAN
Protein Name Rho guanine nucleotide exchange factor 1
Gene Name Name: ARHGEF1
Organism Homo sapiens (Human)

PRO ID PR:Q92888
DAG View
PRO Name Rho guanine nucleotide exchange factor 1 (human)
Definition A Rho guanine nucleotide exchange factor 1 that is encoded in the genome of human.
Short Label hARHGEF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92888 (ARHGEF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S14 Phosphorylation phospho.ELM 18669648
S22 Phosphorylation IEDB 32387766
S102 Phosphorylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   RLIMS-P 32881857
S255 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus   UniProt 24275569
S409 Phosphorylation PhosphoSitePlus   UniProt 23186163
K412 Ubiquitination PhosphoSitePlus
C449 Methylation IEDB 31844290
Y487 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus   UniProt 23186163
K701 Ubiquitination PhosphoSitePlus
Y738 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 20098430
Y738 Phosphorylation O60674 (JAK2) neXtProt   PhosphoSitePlus   Signor 20098430
K763 Ubiquitination PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
S863 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
S876 Phosphorylation PhosphoSitePlus
T912 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 18669648, 20058876
S14 Phosphorylation HPRD 18669648
S776 Phosphorylation HPRD 19651622
S798 Phosphorylation HPRD 20068231
S863 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 18669648, 20058876
S14 Phosphorylation HPRD 18669648
S743 Phosphorylation HPRD 19651622
S765 Phosphorylation HPRD 20068231
S830 Phosphorylation HPRD 18669648, 20068231
S866 Phosphorylation neXtProt 10608806
S866 Phosphorylation Q13535 (ATR) neXtProt 10608806
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S25 Phosphorylation HPRD 18669648, 20058876
S29 Phosphorylation HPRD 18669648
S791 Phosphorylation HPRD 19651622
S813 Phosphorylation HPRD 20068231
S878 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 I22 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S102 N102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S240 L240 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S266 N266 Biomuta DOID:4362 / cervical cancer [ icgc ]
S325 F325 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S350 F350 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S374 I374 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y487 F487 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K567 N567 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S625 P625 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K639 N639 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S876 N876 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]