Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92887 / MRP2_HUMAN
Protein Name Canalicular multispecific organic anion transporter 1
Gene Name Name: ABCC2
Synonyms:CMOAT,CMOAT1,CMRP;
Organism Homo sapiens (Human)

PRO ID PR:Q92887
DAG View
PRO Name canalicular multispecific organic anion transporter 1 (human)
Definition A canalicular multispecific organic anion transporter 1 that is encoded in the genome of human.
Short Label hABCC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92887 (ABCC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S60 Phosphorylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
Y65 Phosphorylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18452278, 18669648, ...20166139, 19415658, 20068231
K294 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
K307 Acetylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
S602 Phosphorylation HPRD   PhosphoSitePlus 18452278
S609 Phosphorylation HPRD   PhosphoSitePlus 18452278
K615 Ubiquitination PhosphoSitePlus
Y616 Phosphorylation HPRD   PhosphoSitePlus 19664994
K716 Ubiquitination PhosphoSitePlus
T723 Phosphorylation HPRD   PhosphoSitePlus 20068231
K728 Ubiquitination PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K852 Acetylation PhosphoSitePlus
K857 Acetylation PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
T873 Phosphorylation HPRD   phospho.ELM 18669648
S878 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 18452278
Y885 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
S900 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S908 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus   UniProt 23186163
S930 Phosphorylation PhosphoSitePlus   UniProt 23186163
S938 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163
K940 Ubiquitination PhosphoSitePlus
K947 Ubiquitination PhosphoSitePlus
K954 Ubiquitination PhosphoSitePlus
S1153 Phosphorylation PhosphoSitePlus
K1184 Ubiquitination PhosphoSitePlus
K1277 Ubiquitination PhosphoSitePlus
K1288 Ubiquitination PhosphoSitePlus
S1296 Phosphorylation PhosphoSitePlus
S1326 Phosphorylation PhosphoSitePlus
T1378 Phosphorylation HPRD 20068231
S1438 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1501 Phosphorylation PhosphoSitePlus
S1542 Phosphorylation RLIMS-P 12615054
K1544 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K294 N294 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K513 N513 Biomuta DOID:3070 / malignant glioma [ tcga ]
K615 N615 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ]
K716 N716 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K728 N728 Biomuta DOID:1324 / lung cancer [ tcga ]
K851 E851 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K857 N857 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K1277 N1277 Biomuta DOID:363 / uterine cancer [ tcga ]
K1288 N1288 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T1378 I1378 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]