iPTMnet Report for Q92878 (RAD50)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92878 / RAD50_HUMAN
Protein Name DNA repair protein RAD50
Gene Name Name: RAD50
Organism Homo sapiens (Human)

PRO ID PR:Q92878
DAG View
PRO Name DNA repair protein RAD50 (human)
Definition A DNA repair protein RAD50 that is encoded in the genome of human.
Short Label hRAD50
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92878 (RAD50) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation IEDB 34357683
K6 Ubiquitination PhosphoSitePlus
K20 Methylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S106 Phosphorylation IEDB 32387766
K112 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K175 Acetylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
R193 Methylation PhosphoSitePlus
T198 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 28510447, 33465208
T198 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
R359 Methylation PhosphoSitePlus
K398 Acetylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
K461 Acetylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
R473 Methylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K585 Acetylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S635 Phosphorylation Q13315 (ATM) , Q13535 (ATR) phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 17525332, 23186163, 17081983, ...17570479, 15302935, 24694934, 18669648, 21757780, 20068231
S640 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T690 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...19690332, 20068231
S703 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 28510447, 33465208
S703 Phosphorylation IEDB 35494241
S717 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 28510447, 33465208
K743 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
C788 Methylation IEDB 31844290
R797 Methylation PhosphoSitePlus
R823 Methylation PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
S872 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 28510447, 33465208
S900 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 28510447, 33465208
K921 Ubiquitination PhosphoSitePlus
K959 Acetylation PhosphoSitePlus   UniProt 19608861
Y964 Phosphorylation PhosphoSitePlus
K982 Ubiquitination PhosphoSitePlus
K1032 Acetylation PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
K1068 Ubiquitination PhosphoSitePlus
K1089 Ubiquitination PhosphoSitePlus
T1113 Phosphorylation PhosphoSitePlus
T1114 Phosphorylation PhosphoSitePlus
K1119 Ubiquitination PhosphoSitePlus
Y1125 Phosphorylation PhosphoSitePlus
K1126 Ubiquitination PhosphoSitePlus
K1134 Ubiquitination PhosphoSitePlus
Y1162 Phosphorylation PhosphoSitePlus
K1178 Ubiquitination PhosphoSitePlus
K1190 Ubiquitination PhosphoSitePlus
K1285 Acetylation PhosphoSitePlus
K1285 Ubiquitination PhosphoSitePlus
K1291 Ubiquitination PhosphoSitePlus
K1301 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T536 Phosphorylation HPRD 20068231
S557 Phosphorylation HPRD 20068231
S560 Phosphorylation HPRD 20068231
S635 Phosphorylation HPRD 18077418, 15302935, 18669648, ...20068231
S640 Phosphorylation HPRD 18669648, 17081983
T690 Phosphorylation HPRD 15302935, 18669648, 19664994, ...20068231, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 N6 Biomuta DOID:1324 / lung cancer [ cosmic ]
R193 W193 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
K238 M238 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K256 Q256 Biomuta DOID:363 / uterine cancer [ cosmic ]
K280 T280 Biomuta DOID:1612 / breast cancer [ cosmic ]
R359 C359 Biomuta DOID:4159 / skin cancer [ cosmic ]
K446 E446 Biomuta DOID:3571 / liver cancer [ cosmic ]
R473 M473 Biomuta DOID:4159 / skin cancer [ cosmic ]
T536 I536 Biomuta DOID:4159 / skin cancer [ cosmic ]
S557 Y557 Biomuta DOID:363 / uterine cancer [ cosmic ]
S557 P557 Biomuta DOID:363 / uterine cancer [ cosmic ]
S560 R560 Biomuta DOID:1612 / breast cancer [ cosmic ]
S624 G624 Biomuta DOID:263 / kidney cancer [ cosmic ]
S635 N635 Biomuta DOID:1319 / brain cancer [ cosmic ]
R797 G797 Biomuta DOID:3571 / liver cancer [ cosmic ]
R823 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R823 Q823 Biomuta DOID:4159 / skin cancer [ cosmic ]
R823 L823 Biomuta DOID:3571 / liver cancer [ cosmic ]
K838 T838 Biomuta DOID:1324 / lung cancer [ cosmic ]
K838 N838 Biomuta DOID:363 / uterine cancer [ cosmic ]
K845 M845 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K1089 N1089 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1126 N1126 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1134 E1134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1190 N1190 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]