iPTMnet Report for Q92854 (SEMA4D)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92854 / SEM4D_HUMAN
Protein Name Semaphorin-4D precursor
Gene Name Name: SEMA4D
Synonyms:C9orf164,CD100,SEMAJ;
Organism Homo sapiens (Human)

PRO ID PR:Q92854
DAG View
PRO Name semaphorin-4D (human)
Definition A semaphorin-4D that is encoded in the genome of human.
Short Label hSEMA4D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92854 (SEMA4D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
N49 N-Glycosylation GlyGen   UniProt 20877282, 19349973
N74 N-Glycosylation GlyGen 24190977
N77 N-Glycosylation GlyGen   UniProt 24190977, 20877282, 29391424, ...19349973
K81 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
N139 N-Glycosylation GlyGen   UniProt 20877282
K148 Ubiquitination PhosphoSitePlus
N191 N-Glycosylation GlyGen   UniProt 20877282, 29391424
K269 Acetylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
N329 N-Glycosylation GlyGen   UniProt 20877282
N379 N-Glycosylation GlyGen   UniProt 23090970, 24190977, 29391424, ...19349973
T390 Phosphorylation PhosphoSitePlus
N419 N-Glycosylation GlyGen   UniProt 24190977, 23090970, 29391424, ...19349973, 16263699, 20877282, 29741879
K505 Ubiquitination PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
T657 O-Glycosylation GlyGen   PhosphoSitePlus 30459171, 25813380, 35132862, ...23584533, 32574038
S659 O-Glycosylation GlyGen 32574038, 35132862
T663 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S666 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T670 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T696 O-Glycosylation GlyGen 30459171
T716 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S722 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 32574038
Y727 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
Y815 Phosphorylation PhosphoSitePlus
T817 Phosphorylation PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus   UniProt 23186163
S840 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S195 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 P5 Biomuta DOID:10534 / stomach cancer [ cosmic ]
N139 S139 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T390 M390 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T657 S657 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T716 M716 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S722 L722 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S840 F840 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]