Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92844 / TANK_HUMAN
Protein Name TRAF family member-associated NF-kappa-B activator
Gene Name Name: TANK
Synonyms:ITRAF,TRAF2;
Organism Homo sapiens (Human)

PRO ID PR:Q92844
DAG View
PRO Name TRAF family member-associated NF-kappa-B activator (human)
Definition A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of human.
Short Label hTANK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92844 (TANK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
M1 Acetylation UniProt 22814378
S49 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus 21138416, 10759890
K57 Ubiquitination PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S100 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus 21138416, 10759890
S117 Phosphorylation PhosphoSitePlus
S126 Phosphorylation Q14164 (IKBKE) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 23186163, 10759890, ...18669648, 24275569, 21138416
S129 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...19369195
K165 Ubiquitination PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus   UniProt 21138416, 24275569, 10759890
K186 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
S208 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus   UniProt 23186163, 21138416, 24275569, ...10759890
T213 Phosphorylation PhosphoSitePlus   UniProt 23186163
S225 Phosphorylation PhosphoSitePlus   UniProt 23186163
S228 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus   UniProt 23186163, 21138416, 10759890
S230 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S257 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus 21138416, 10759890
S261 Phosphorylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
T283 O-Glycosylation GlyGen 23301498, 29351928
T286 O-Glycosylation GlyGen 23301498, 29351928
K304 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
Y338 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus   UniProt 19369195
S354 Phosphorylation PhosphoSitePlus   UniProt 19369195
S357 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648
K371 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S406 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus 21138416, 10759890
S409 Phosphorylation Q14164 (IKBKE) neXtProt 21138416, 10759890
Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation HPRD 18691976
S117 Phosphorylation HPRD 18691976
S126 Phosphorylation HPRD 18669648
S129 Phosphorylation HPRD 18691976, 18669648, 20068231
S208 Phosphorylation HPRD 18691976
T213 Phosphorylation HPRD 18691976
S225 Phosphorylation HPRD 18691976, 17081983, 20068231
S228 Phosphorylation HPRD 18691976, 17081983
S243 Phosphorylation HPRD 18691976
T249 Phosphorylation HPRD 18691976
S257 Phosphorylation HPRD 18691976
S354 Phosphorylation HPRD 18691976
S357 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049397 (hTANK/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S116 P116 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S117 C117 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
T171 I171 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S225 C225 Biomuta DOID:1324 / lung cancer [ tcga ]
S257 G257 Biomuta DOID:363 / uterine cancer [ tcga ]
K304 T304 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K308 T308 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S354 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S357 Y357 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S380 L380 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:263 / kidney cancer [ icgc, tcga ]