iPTMnet Report for Q92824 (PCSK5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92824 / PCSK5_HUMAN
Protein Name Proprotein convertase subtilisin/kexin type 5 precursor
Gene Name Name: PCSK5
Synonyms:PC5,PC6;
Organism Homo sapiens (Human)

PRO ID PR:Q92824
DAG View
PRO Name proprotein convertase subtilisin/kexin type 5 (human)
Definition A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of human.
Short Label hPCSK5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92824 (PCSK5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
T754 Phosphorylation PhosphoSitePlus
Y1263 Phosphorylation PhosphoSitePlus
S1264 Phosphorylation PhosphoSitePlus
S1270 Phosphorylation PhosphoSitePlus
Y1271 Phosphorylation PhosphoSitePlus
S1424 Phosphorylation PhosphoSitePlus
T1436 Phosphorylation PhosphoSitePlus
S1572 Phosphorylation PhosphoSitePlus
S1596 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y72 D72 Biomuta DOID:10283 / prostate cancer [ icgc ]
Y75 S75 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1424 F1424 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1424 Y1424 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S1596 F1596 Biomuta DOID:4159 / skin cancer [ cosmic ]