iPTMnet Report for Q92817 (EVPL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92817 / EVPL_HUMAN
Protein Name Envoplakin
Gene Name Name: EVPL
Organism Homo sapiens (Human)

PRO ID PR:Q92817
DAG View
PRO Name envoplakin (human)
Definition An envoplakin that is encoded in the genome of human.
Short Label hEVPL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92817 (EVPL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Methylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S18 Phosphorylation HPRD   PhosphoSitePlus 18767875
S23 Phosphorylation PhosphoSitePlus
S27 O-Glycosylation GlyGen 31492838, 30397120
S27 Phosphorylation PhosphoSitePlus
S29 O-Glycosylation GlyGen 31492838, 30397120
S29 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
S219 Phosphorylation HPRD   PhosphoSitePlus 20068231
S224 Phosphorylation PhosphoSitePlus
S227 Phosphorylation HPRD 20068231
T230 Phosphorylation HPRD 20068231
S346 Phosphorylation PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation HPRD 20068231
S361 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
S904 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus
Y963 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
T1009 Phosphorylation PhosphoSitePlus
K1065 Ubiquitination PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
T1206 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus
T1254 Phosphorylation PhosphoSitePlus
S1263 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1352 Phosphorylation PhosphoSitePlus
S1392 Phosphorylation HPRD   PhosphoSitePlus 19691289
K1451 Ubiquitination PhosphoSitePlus
T1455 Phosphorylation PhosphoSitePlus
K1467 Ubiquitination PhosphoSitePlus
K1476 Ubiquitination PhosphoSitePlus
Y1520 Phosphorylation PhosphoSitePlus
S1617 Phosphorylation PhosphoSitePlus
S1621 Phosphorylation PhosphoSitePlus
K1649 Acetylation PhosphoSitePlus
Y1653 Phosphorylation PhosphoSitePlus
S1667 Phosphorylation PhosphoSitePlus
S1698 Phosphorylation PhosphoSitePlus
Y1700 Phosphorylation PhosphoSitePlus
Y1703 Phosphorylation PhosphoSitePlus
Y1766 Phosphorylation IEDB 35494241
S1799 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S1813 Phosphorylation HPRD 20068231
T1865 Phosphorylation PhosphoSitePlus
S1873 Phosphorylation PhosphoSitePlus
T1911 Phosphorylation PhosphoSitePlus
S1916 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1988 Acetylation PhosphoSitePlus
Y1993 Phosphorylation PhosphoSitePlus
S2006 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y2018 Phosphorylation HPRD   PhosphoSitePlus 20068231
S2025 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 19691289


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K95 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S219 A219 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K500 R500 Biomuta DOID:3571 / liver cancer [ cosmic ]
K583 N583 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y752 * Biomuta DOID:1319 / brain cancer [ cosmic ]
T1009 I1009 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1065 R1065 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1206 A1206 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1263 N1263 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1455 K1455 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1455 M1455 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1667 N1667 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1799 F1799 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1813 F1813 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1813 C1813 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1865 K1865 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1911 N1911 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1916 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S1916 L1916 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2006 I2006 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y2018 C2018 Biomuta DOID:10534 / stomach cancer [ icgc ]