Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92797 / SYMPK_HUMAN
Protein Name Symplekin
Gene Name Name: SYMPK
Synonyms:SPK;
Organism Homo sapiens (Human)

PRO ID PR:Q92797
DAG View
PRO Name symplekin (human)
Definition A symplekin that is encoded in the genome of human.
Short Label hSYMPK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92797 (SYMPK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus   UniProt 23186163
S16 Phosphorylation PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
R215 Methylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
K358 Acetylation PhosphoSitePlus
K361 Sumoylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K483 Sumoylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
S501 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
Y624 Phosphorylation PhosphoSitePlus
Y627 Phosphorylation PhosphoSitePlus
Y642 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K684 Acetylation PhosphoSitePlus
Y693 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
T698 Phosphorylation PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
K912 Ubiquitination PhosphoSitePlus
K919 Ubiquitination PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
K960 Ubiquitination PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
Y1031 Phosphorylation PhosphoSitePlus
K1040 Ubiquitination PhosphoSitePlus
T1083 Phosphorylation PhosphoSitePlus
K1103 Ubiquitination PhosphoSitePlus
K1147 Ubiquitination PhosphoSitePlus
K1150 Methylation PhosphoSitePlus
K1160 Ubiquitination PhosphoSitePlus
S1168 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1173 Phosphorylation PhosphoSitePlus
S1175 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1177 Phosphorylation PhosphoSitePlus
S1185 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1222 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1231 O-Glycosylation GlyGen 29351928
T1231 Phosphorylation PhosphoSitePlus
T1237 Phosphorylation PhosphoSitePlus
K1239 Acetylation PhosphoSitePlus
K1239 Sumoylation PhosphoSitePlus
S1243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...24275569, 20068231
T1246 Phosphorylation PhosphoSitePlus
T1257 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S1259 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S1274 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T132 Phosphorylation HPRD 20068231
Y137 Phosphorylation HPRD 20068231
T455 Phosphorylation HPRD 20068231
T458 Phosphorylation HPRD 20068231
T469 Phosphorylation HPRD 20068231
S486 Phosphorylation HPRD 20068231
S494 Phosphorylation HPRD 20068231, 18452278
S501 Phosphorylation HPRD 18452278
S508 Phosphorylation HPRD 18691976
S547 Phosphorylation HPRD 20068231
S1021 Phosphorylation HPRD 20068231
S1168 Phosphorylation HPRD 20068231
S1169 Phosphorylation HPRD 19651622
S1171 Phosphorylation HPRD 19651622, 18669648, 16964243, ...20068231
S1173 Phosphorylation HPRD 19651622, 18452278
S1175 Phosphorylation HPRD 18669648, 19664994, 18452278
S1185 Phosphorylation HPRD 20068231
S1221 Phosphorylation HPRD 20058876
S1222 Phosphorylation HPRD 20058876
S1243 Phosphorylation HPRD 15302935, 19664994, 18452278, ...19651622, 18669648, 20068231
T1246 Phosphorylation HPRD 20068231
T1257 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18452278
S1259 Phosphorylation HPRD 19651622, 18669648, 19664995, ...18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 R8 Biomuta DOID:3571 / liver cancer [ icgc ]
Y137 * Biomuta DOID:3571 / liver cancer [ icgc ]
R215 H215 Biomuta DOID:1909 / melanoma [ cosmic ]
R215 P215 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S353 * Biomuta DOID:3571 / liver cancer [ icgc ]
T469 S469 Biomuta DOID:1612 / breast cancer [ icgc ]
K520 N520 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S547 R547 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y627 C627 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y642 C642 Biomuta DOID:1612 / breast cancer [ tcga ]
K705 N705 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1185 C1185 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1221 C1221 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T1231 M1231 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1243 R1243 Biomuta DOID:3571 / liver cancer [ icgc ]