iPTMnet Report for Q92793 (CREBBP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92793 / CBP_HUMAN
Protein Name CREB-binding protein
Gene Name Name: CREBBP
Synonyms:CBP;
Organism Homo sapiens (Human)

PRO ID PR:Q92793
DAG View
PRO Name CREB-binding protein (human)
Definition A CREB-binding protein that is encoded in the genome of human.
Short Label hCREBBP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92793 (CREBBP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
K13 Acetylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S92 Phosphorylation RLIMS-P 21751375
S93 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) PhosphoSitePlus 21751375
S121 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S124 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S129 Phosphorylation PhosphoSitePlus
S139 O-Glycosylation GlyGen 33214551, 32938750, 35138101, ...30379171, 32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S141 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
T144 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S148 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S202 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S212 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
R218 Methylation PhosphoSitePlus
R220 Methylation PhosphoSitePlus   UniProt 24129315
S274 Phosphorylation PhosphoSitePlus
S281 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S302 Phosphorylation phospho.ELM 11970865
T320 Phosphorylation PhosphoSitePlus
S326 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
T330 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
K366 Acetylation PhosphoSitePlus
K389 Acetylation PhosphoSitePlus
S437 Phosphorylation phospho.ELM   PhosphoSitePlus 11463380
R601 Methylation PhosphoSitePlus
K622 Acetylation PhosphoSitePlus
K657 Acetylation PhosphoSitePlus
Y659 Phosphorylation PhosphoSitePlus
R714 Methylation PhosphoSitePlus
R742 Methylation PhosphoSitePlus
R768 Methylation PhosphoSitePlus
S868 Phosphorylation IEDB 32387766
T1001 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K1014 Acetylation PhosphoSitePlus   UniProt 19608861
S1019 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K1033 Sumoylation PhosphoSitePlus
K1042 Acetylation PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus
K1056 Sumoylation PhosphoSitePlus
T1070 Phosphorylation PhosphoSitePlus
S1072 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1076 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1125 Phosphorylation PhosphoSitePlus
T1171 Phosphorylation PhosphoSitePlus
K1203 Acetylation PhosphoSitePlus
K1216 Acetylation PhosphoSitePlus   UniProt 19608861
R1341 Methylation PhosphoSitePlus
K1367 Acetylation PhosphoSitePlus
K1376 Acetylation PhosphoSitePlus
S1382 Phosphorylation O15111 (CHUK) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17434128
S1386 Phosphorylation O15111 (CHUK) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17434128
Y1391 Phosphorylation PhosphoSitePlus
K1524 Ubiquitination PhosphoSitePlus
K1535 Acetylation PhosphoSitePlus
K1535 Ubiquitination PhosphoSitePlus
Y1539 Phosphorylation IEDB 35494241
K1564 Acetylation PhosphoSitePlus
K1565 Methylation PhosphoSitePlus
S1568 Phosphorylation PhosphoSitePlus
T1569 Phosphorylation PhosphoSitePlus
S1578 Phosphorylation PhosphoSitePlus
K1583 Acetylation PhosphoSitePlus   UniProt 19608861
K1586 Acetylation PhosphoSitePlus
K1587 Acetylation PhosphoSitePlus
K1588 Acetylation PhosphoSitePlus
K1591 Acetylation PhosphoSitePlus   UniProt 19608861
K1592 Acetylation PhosphoSitePlus   UniProt 19608861
K1595 Acetylation PhosphoSitePlus   UniProt 19608861
K1597 Acetylation PhosphoSitePlus   UniProt 19608861
K1620 Acetylation PhosphoSitePlus
Y1622 Phosphorylation PhosphoSitePlus
K1627 Acetylation PhosphoSitePlus
T1669 Phosphorylation PhosphoSitePlus
T1697 Phosphorylation PhosphoSitePlus
K1711 Acetylation PhosphoSitePlus
K1736 Acetylation PhosphoSitePlus
K1741 Acetylation PhosphoSitePlus   UniProt 19608861
K1744 Acetylation PhosphoSitePlus   UniProt 19608861
S1754 Phosphorylation PhosphoSitePlus
S1755 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K1762 Acetylation PhosphoSitePlus
S1763 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1791 Phosphorylation PhosphoSitePlus
K1797 Acetylation PhosphoSitePlus
K1799 Acetylation PhosphoSitePlus
K1806 Acetylation PhosphoSitePlus
K1809 Acetylation PhosphoSitePlus
K1831 Acetylation PhosphoSitePlus
K1837 Acetylation PhosphoSitePlus
T1871 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 23434580
T1874 Phosphorylation PhosphoSitePlus
K1937 Acetylation PhosphoSitePlus
Y1973 Phosphorylation PhosphoSitePlus
S2041 Phosphorylation PhosphoSitePlus
S2063 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...19690332
S2065 Phosphorylation PhosphoSitePlus
T2073 Phosphorylation PhosphoSitePlus
K2075 Ubiquitination PhosphoSitePlus
S2076 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S2078 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2079 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K2102 Ubiquitination PhosphoSitePlus
R2151 Methylation PhosphoSitePlus
S2322 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S2328 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
T2337 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S2338 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S2351 Phosphorylation PhosphoSitePlus
R2353 Methylation PhosphoSitePlus
S2356 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S2356 Phosphorylation PhosphoSitePlus
S2361 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S2361 Phosphorylation PhosphoSitePlus
S2362 Phosphorylation PhosphoSitePlus
S2364 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 29351928, 35132862, 31492838, 32119511, 35254053, 15327282, 29237092
S2364 Phosphorylation PhosphoSitePlus
T2390 O-Glycosylation GlyGen 32574038
S2406 Phosphorylation PhosphoSitePlus
S2422 Phosphorylation PhosphoSitePlus
S2425 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S121 Phosphorylation HPRD 19651622, 18669648, 19664994, ...20068231
S124 Phosphorylation HPRD 17525332
S274 Phosphorylation HPRD 19413330
S302 Phosphorylation Q16566 (CAMK4) HPRD 11970865
S437 Phosphorylation Q05655 (PRKCD) HPRD 11463380
T1001 Phosphorylation HPRD 17525332
S1030 Phosphorylation HPRD 17525332
S1072 Phosphorylation HPRD 17525332
S1076 Phosphorylation HPRD 19664994, 18452278
S1755 Phosphorylation HPRD 17525332
S1763 Phosphorylation HPRD 20068231
S1771 Phosphorylation HPRD 20068231
S2063 Phosphorylation HPRD 19413330, 18669648, 20058876, ...18452278
S2076 Phosphorylation HPRD 18669648
S2078 Phosphorylation HPRD 18669648, 20068231
S2079 Phosphorylation HPRD 19413330, 18669648
S2322 Phosphorylation HPRD 20068231
S2372 Phosphorylation HPRD 20068231
S2377 Phosphorylation HPRD 20068231
S2382 Phosphorylation HPRD 20068231
T2390 Phosphorylation HPRD 20068231
S2394 Phosphorylation HPRD 20068231
S2406 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S121 Phosphorylation HPRD 19651622, 18669648, 19664994, ...20068231
S124 Phosphorylation HPRD 17525332
S274 Phosphorylation HPRD 19413330
T963 Phosphorylation HPRD 17525332
S992 Phosphorylation HPRD 17525332
S1034 Phosphorylation HPRD 17525332
S1038 Phosphorylation HPRD 19664994, 18452278
S1717 Phosphorylation HPRD 17525332
S1725 Phosphorylation HPRD 20068231
S1733 Phosphorylation HPRD 20068231
S2025 Phosphorylation HPRD 19413330, 18669648, 20058876, ...18452278
S2038 Phosphorylation HPRD 18669648
S2040 Phosphorylation HPRD 18669648, 20068231
S2041 Phosphorylation HPRD 19413330, 18669648
S2284 Phosphorylation HPRD 20068231
S2334 Phosphorylation HPRD 20068231
S2339 Phosphorylation HPRD 20068231
S2344 Phosphorylation HPRD 20068231
T2352 Phosphorylation HPRD 20068231
S2356 Phosphorylation HPRD 20068231
S2368 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S15 Q92793 (CREBBP) increased_association eFIP 9830059
Phosphorylation P04637 (TP53) T18 Q92793 (CREBBP) increased_association eFIP 19357310
Phosphorylation P51812 (RPS6KA3) S227 Q92793 (CREBBP) unknown eFIP 31382504
Phosphorylation Q04206 (RELA) S468 Q92793 (CREBBP) unknown eFIP 25450975
Phosphorylation Q14653 (IRF3) S396 Q92793 (CREBBP) unknown eFIP 28589097


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036862 (hCTNNB1/iso:1/Phos:5) increased Interaction PR:Q92793 (hCREBBP) PRO 16476742
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q16665 (hHIF1A) PRO 9887100
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q99967-1 (hCITED2/iso:1) PRO 99104162
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q04206 (hRELA) PRO 16291753
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q9UER7 (hDAXX) PRO 11799127
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q14686 (hNCOA6) PRO 10866662
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:P55209 (hNAP1L1) PRO 11940655
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q92793 (hCREBBP) PRO 8684459
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:P17096 (hHMGA1) PRO 10428834
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:P42858 (hHTT) PRO 10823891
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:P04637 (hTP53) PRO 9194564


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S78 C78 Biomuta DOID:1324 / lung cancer [ cosmic ]
S121 I121 Biomuta DOID:363 / uterine cancer [ cosmic ]
S129 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S129 L129 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S139 N139 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R218 I218 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R218 T218 Biomuta DOID:1324 / lung cancer [ cosmic ]
R218 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S274 N274 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S302 R302 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S302 N302 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T320 I320 Biomuta DOID:363 / uterine cancer [ cosmic ]
S326 F326 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R601 Q601 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R601 W601 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K622 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K657 N657 Biomuta DOID:363 / uterine cancer [ icgc ]
Y659 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R714 P714 Biomuta DOID:4159 / skin cancer [ cosmic ]
R714 S714 Biomuta DOID:363 / uterine cancer [ icgc ]
R714 H714 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R714 C714 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
R742 C742 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R742 L742 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R742 P742 Biomuta DOID:3119 / gastrointestinal system cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R768 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S992 F992 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1019 C1019 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1030 F1030 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1034 F1034 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1072 F1072 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1125 H1125 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1125 C1125 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y1125 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T1171 I1171 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K1203 * Biomuta DOID:3571 / liver cancer [ cosmic ]
R1341 P1341 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R1341 Q1341 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R1341 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
K1367 N1367 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1386 C1386 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1539 D1539 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1539 * Biomuta DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K1564 E1564 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1578 C1578 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1588 N1588 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K1595 N1595 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K1597 E1597 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1622 H1622 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y1622 C1622 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1754 N1754 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1762 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1791 P1791 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1806 N1806 Biomuta DOID:263 / kidney cancer [ cosmic ]
K1809 R1809 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1837 R1837 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T1874 I1874 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1973 H1973 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S2038 L2038 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S2041 F2041 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2065 N2065 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2076 L2076 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S2079 F2079 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R2151 W2151 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R2151 Q2151 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S2284 L2284 Biomuta DOID:1319 / brain cancer [ cosmic ]
S2322 L2322 Biomuta DOID:1319 / brain cancer [ cosmic ]
S2328 L2328 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S2334 L2334 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S2334 W2334 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2338 C2338 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2338 F2338 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S2339 A2339 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2339 L2339 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S2344 F2344 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S2351 F2351 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T2352 N2352 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R2353 W2353 Biomuta DOID:1324 / lung cancer [ cosmic ]
R2353 L2353 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2356 F2356 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2356 P2356 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S2361 F2361 Biomuta [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S2372 L2372 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S2372 W2372 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2377 L2377 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S2377 A2377 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2382 F2382 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T2390 N2390 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]