iPTMnet Report for Q92786 (PROX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92786 / PROX1_HUMAN
Protein Name Prospero homeobox protein 1
Gene Name Name: PROX1
Organism Homo sapiens (Human)

PRO ID PR:Q92786
DAG View
PRO Name prospero homeobox protein 1 (human)
Definition A prospero homeobox protein 1 that is encoded in the genome of human.
Short Label hPROX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92786 (PROX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD   PhosphoSitePlus 20166139
Y80 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus   UniProt 24275569
S179 Phosphorylation HPRD   PhosphoSitePlus 20166139
S181 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S199 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
S291 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus   UniProt 24275569
K353 Sumoylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S511 Phosphorylation HPRD   PhosphoSitePlus 20166139
S514 Phosphorylation HPRD   PhosphoSitePlus 20166139
S539 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
K556 Sumoylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus   UniProt 24275569
K707 Acetylation PhosphoSitePlus
K708 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S79 L79 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S94 F94 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S181 I181 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S197 Y197 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S197 F197 Biomuta DOID:4159 / skin cancer [ cosmic ]
S372 L372 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S372 P372 Biomuta DOID:263 / kidney cancer [ cosmic ]
S553 L553 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K556 Q556 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S557 C557 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]