Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92769 / HDAC2_HUMAN
Protein Name Histone deacetylase 2
Gene Name Name: HDAC2
Organism Homo sapiens (Human)

PRO ID PR:Q92769
DAG View
PRO Name histone deacetylase 2 (human)
Definition A histone deacetylase 2 that is encoded in the genome of human.
Short Label hHDAC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92769 (HDAC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation RLIMS-P 29190394
K11 Ubiquitination PhosphoSitePlus
R37 Methylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K90 Methylation PhosphoSitePlus
K90 Sumoylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation P00519 (ABL1) PhosphoSitePlus 25219501
K243 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
C262 S-Nitrosylation dbSNO 18754010, 19047631
C274 S-Nitrosylation dbSNO 18754010, 19047631
K280 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
K343 Sumoylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
R366 Methylation PhosphoSitePlus
S394 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 21406692, 23186163, ...17081983, 20388487, 30109767, 18669648, 12176973, 24234443, 24275569, 25609639, 21576649, 12082111, 19690332, 20068231
S407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163
S411 Phosphorylation PhosphoSitePlus
C417 S-Nitrosylation dbSNO 26338901
S422 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17287340, 17081983, ...18669648, 12176973, 24275569, 23186163, 12082111, 19690332, 20068231
S424 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 17287340, 17081983, ...18669648, 12176973, 24275569, 23186163, 12082111, 19486889, 20068231
K439 Acetylation PhosphoSitePlus
K462 Sumoylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
K481 Sumoylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92769 (HDAC2) S424 O43474 (KLF4) inhibited_association eFIP 19486889


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:Q92769 (hHDAC2) PRO
PR:P29590-5 (hPML/iso:5) Interaction PR:Q92769 (hHDAC2) PRO 11259576


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R37 H37 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ tcga ]
R37 C37 Biomuta DOID:363 / uterine cancer [ tcga ]
K90 N90 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K201 E201 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y334 C334 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K362 N362 Biomuta DOID:363 / uterine cancer [ tcga ]
R366 C366 Biomuta DOID:363 / uterine cancer [ tcga ]
R366 H366 Biomuta DOID:1909 / melanoma [ cosmic ]
S424 F424 Biomuta DOID:363 / uterine cancer [ tcga ]