iPTMnet Report for Q92766 (RREB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92766 / RREB1_HUMAN
Protein Name Ras-responsive element-binding protein 1
Gene Name Name: RREB1
Synonyms:FINB;
Organism Homo sapiens (Human)

PRO ID PR:Q92766
DAG View
PRO Name Ras-responsive element-binding protein 1 (human)
Definition A Ras-responsive element-binding protein 1 that is encoded in the genome of human.
Short Label hRREB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92766 (RREB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
S36 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 20068231
S42 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S44 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S120 O-Glycosylation GlyGen 30379171, 35132862, 30620550, ...35254053
S120 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231, ...24275569
S175 Phosphorylation PhosphoSitePlus   UniProt 23186163
S180 Phosphorylation PhosphoSitePlus   UniProt 23186163
T229 Phosphorylation PhosphoSitePlus
S231 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
K347 Ubiquitination PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
T407 Phosphorylation IEDB 35494241
K435 Ubiquitination PhosphoSitePlus
S485 O-Glycosylation GlyGen 30379171, 35132862, 30620550, ...35254053
S490 O-Glycosylation GlyGen 32938750
K508 Ubiquitination PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
T517 O-Glycosylation GlyGen 30379171, 35132862, 30620550, ...35254053
K551 Sumoylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
K615 Sumoylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
K633 Acetylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
Y706 Phosphorylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
K1085 Ubiquitination PhosphoSitePlus
T1094 O-Glycosylation GlyGen 30379171, 35132862, 32938750, ...30620550, 35254053
S1103 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus
T1120 Phosphorylation PhosphoSitePlus
T1121 Phosphorylation phospho.ELM 18669648
S1122 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1134 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1161 Phosphorylation PhosphoSitePlus
S1167 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 27920218, ...18669648, 30784271, 19690332, 20068231
S1174 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S1175 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S1180 Phosphorylation PhosphoSitePlus
S1194 Phosphorylation PhosphoSitePlus
T1199 Phosphorylation PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S1225 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1238 Phosphorylation PhosphoSitePlus
T1267 Phosphorylation phospho.ELM 18669648
T1269 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1273 Phosphorylation PhosphoSitePlus
T1277 Phosphorylation PhosphoSitePlus
T1315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1318 Phosphorylation PhosphoSitePlus
S1320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1388 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K1400 Acetylation PhosphoSitePlus
S1401 Phosphorylation PhosphoSitePlus
T1407 Phosphorylation PhosphoSitePlus
S1409 Phosphorylation PhosphoSitePlus
S1475 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1479 Phosphorylation PhosphoSitePlus
S1489 Phosphorylation PhosphoSitePlus
S1499 Phosphorylation PhosphoSitePlus
S1502 Phosphorylation PhosphoSitePlus
T1528 O-Glycosylation GlyGen 30379171, 35132862, 30620550, ...35254053
T1535 Phosphorylation PhosphoSitePlus
T1544 Phosphorylation PhosphoSitePlus
T1548 Phosphorylation PhosphoSitePlus
T1550 Phosphorylation PhosphoSitePlus
S1554 Phosphorylation PhosphoSitePlus
S1575 Phosphorylation PhosphoSitePlus
S1585 Phosphorylation PhosphoSitePlus
S1589 Phosphorylation PhosphoSitePlus
S1592 Phosphorylation PhosphoSitePlus
S1598 Phosphorylation PhosphoSitePlus
S1609 Phosphorylation PhosphoSitePlus
T1615 Phosphorylation PhosphoSitePlus
S1624 Phosphorylation PhosphoSitePlus
S1653 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S1681 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T31 Phosphorylation HPRD 20068231
S36 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S42 Phosphorylation HPRD 18669648, 20068231
S120 Phosphorylation HPRD 20068231
S161 Phosphorylation HPRD 19651622, 20058876, 20068231
S231 Phosphorylation HPRD 18669648, 20068231, 18452278
T628 Phosphorylation HPRD 20068231
S1103 Phosphorylation HPRD 20068230
T1120 Phosphorylation HPRD 20068231
T1121 Phosphorylation HPRD 18669648
S1122 Phosphorylation HPRD 19413330, 19651622, 20068231, ...20068230
S1167 Phosphorylation HPRD 15302935, 19664994, 18452278, ...19651622, 18669648, 20068231
S1174 Phosphorylation HPRD 18669648, 20068231, 18452278
S1175 Phosphorylation HPRD 18669648, 20068231, 18452278
S1219 Phosphorylation HPRD 18669648, 18452278
S1225 Phosphorylation HPRD 18669648, 18452278
T1267 Phosphorylation HPRD 18669648
S1271 Phosphorylation HPRD 18669648
T1315 Phosphorylation HPRD 18669648, 20068231
T1318 Phosphorylation HPRD 19651622, 17081983
S1320 Phosphorylation HPRD 18669648, 20068231
S1388 Phosphorylation HPRD 17525332
S1489 Phosphorylation HPRD 19664994
S1585 Phosphorylation HPRD 18452278
S1653 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T31 Phosphorylation HPRD 20068231
S36 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S42 Phosphorylation HPRD 18669648, 20068231
S120 Phosphorylation HPRD 20068231
S161 Phosphorylation HPRD 19651622, 20058876, 20068231
S231 Phosphorylation HPRD 18669648, 20068231, 18452278
T628 Phosphorylation HPRD 20068231
S1103 Phosphorylation HPRD 20068230
T1120 Phosphorylation HPRD 20068231
T1121 Phosphorylation HPRD 18669648
S1122 Phosphorylation HPRD 19413330, 19651622, 20068231, ...20068230
S1167 Phosphorylation HPRD 15302935, 19664994, 18452278, ...19651622, 18669648, 20068231
S1174 Phosphorylation HPRD 18669648, 20068231, 18452278
S1175 Phosphorylation HPRD 18669648, 20068231, 18452278
S1219 Phosphorylation HPRD 18669648, 18452278
S1225 Phosphorylation HPRD 18669648, 18452278
K1296 Ubiquitination PhosphoSitePlus
T1300 Phosphorylation PhosphoSitePlus
T1301 Phosphorylation PhosphoSitePlus
S1303 Phosphorylation PhosphoSitePlus
S1313 Phosphorylation PhosphoSitePlus
T1370 Phosphorylation HPRD 18669648, 20068231
T1373 Phosphorylation HPRD 19651622, 17081983
S1375 Phosphorylation HPRD 18669648, 20068231
S1443 Phosphorylation HPRD 17525332
S1544 Phosphorylation HPRD 19664994
S1640 Phosphorylation HPRD 18452278
S1708 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T2 P2 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T2 M2 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S36 R36 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S36 G36 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S42 P42 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S42 F42 Biomuta DOID:4159 / skin cancer [ cosmic ]
S120 F120 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S120 C120 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S161 P161 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S231 L231 Biomuta DOID:4159 / skin cancer [ cosmic ]
S231 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
T351 M351 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T517 M517 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K640 R640 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S1107 F1107 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1140 F1140 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1161 R1161 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1174 F1174 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1175 N1175 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1194 G1194 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1219 C1219 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1271 R1271 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1277 N1277 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1315 M1315 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1320 L1320 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T1370 M1370 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1375 L1375 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1388 L1388 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S1443 L1443 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc, cosmic, cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1499 Y1499 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T1548 S1548 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T1548 A1548 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1592 N1592 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1615 A1615 Biomuta DOID:9256 / colorectal cancer [ cosmic ]