iPTMnet Report for Q92738 (USP6NL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92738 / US6NL_HUMAN
Protein Name USP6 N-terminal-like protein
Gene Name Name: USP6NL
Synonyms:KIAA0019;
Organism Homo sapiens (Human)

PRO ID PR:Q92738
DAG View
PRO Name USP6 N-terminal-like protein (human)
Definition A USP6 N-terminal-like protein that is encoded in the genome of human.
Short Label hUSP6NL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92738 (USP6NL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K10 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
R135 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S391 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S396 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S400 Phosphorylation PhosphoSitePlus   UniProt 23186163
S405 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
R509 Methylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
S585 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15144186
S595 Phosphorylation PhosphoSitePlus
K602 Methylation PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus
S617 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S631 Phosphorylation PhosphoSitePlus
Y632 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
Y638 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus   UniProt 20068231, 24275569
T648 Phosphorylation PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus   UniProt 20068231
S659 Phosphorylation PhosphoSitePlus   UniProt 20068231
S673 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
Y685 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
T705 Phosphorylation PhosphoSitePlus
Y710 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S711 Phosphorylation phospho.ELM 18669648
S714 Phosphorylation PhosphoSitePlus
S716 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15144186, ...18669648, 24275569, 19690332, 20068231
Y729 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
Y741 Phosphorylation PhosphoSitePlus
Y743 Phosphorylation PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
S784 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y788 Phosphorylation PhosphoSitePlus
S791 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S798 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y802 Phosphorylation PhosphoSitePlus
Y804 Phosphorylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
Y812 Phosphorylation PhosphoSitePlus
Y814 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S408 Phosphorylation HPRD 18669648
S413 Phosphorylation HPRD 18669648
S511 Phosphorylation HPRD 18491316
S634 Phosphorylation HPRD 17525332
S659 Phosphorylation HPRD 20068231
S672 Phosphorylation HPRD 20068231
S676 Phosphorylation HPRD 20068231
S697 Phosphorylation HPRD 17322306, 20068231
S728 Phosphorylation HPRD 18669648, 20068231
S731 Phosphorylation HPRD 19664995, 20068231
S733 Phosphorylation HPRD 19413330, 18767875, 18669648, ...19664995, 20068231
S801 Phosphorylation HPRD 18669648
S808 Phosphorylation HPRD 18669648
S815 Phosphorylation HPRD 18669648
Y821 Phosphorylation HPRD 15592455
Y831 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R135 W135 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R135 L135 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S400 N400 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S455 W455 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S455 L455 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S494 L494 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R509 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S511 L511 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S549 L549 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y551 H551 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S631 F631 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S676 F676 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T705 N705 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S716 L716 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y729 S729 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y729 C729 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S733 L733 Biomuta DOID:4159 / skin cancer [ cosmic ]
S765 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S765 L765 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
S781 F781 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S791 L791 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S798 N798 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S808 L808 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y812 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S815 N815 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]