iPTMnet Report for Q92736 (RYR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92736 / RYR2_HUMAN
Protein Name Ryanodine receptor 2
Gene Name Name: RYR2
Organism Homo sapiens (Human)

PRO ID PR:Q92736
DAG View
PRO Name ryanodine receptor 2 (human)
Definition A ryanodine receptor 2 that is encoded in the genome of human.
Short Label hRYR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92736 (RYR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S170 Phosphorylation PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
Y823 Phosphorylation PhosphoSitePlus
Y970 Phosphorylation PhosphoSitePlus
S1049 Phosphorylation PhosphoSitePlus
K1141 Acetylation PhosphoSitePlus
T1172 Phosphorylation PhosphoSitePlus
T1176 Phosphorylation PhosphoSitePlus
T1317 Phosphorylation PhosphoSitePlus
T1468 O-Glycosylation GlyGen 28657654
S1483 Phosphorylation PhosphoSitePlus
Y1486 Phosphorylation PhosphoSitePlus
K1788 Acetylation PhosphoSitePlus
K1790 Acetylation PhosphoSitePlus
K1887 Acetylation PhosphoSitePlus
K1890 Acetylation PhosphoSitePlus
K1897 Acetylation PhosphoSitePlus
K1903 Acetylation PhosphoSitePlus
Y1944 Phosphorylation PhosphoSitePlus
T1962 Phosphorylation PhosphoSitePlus
S2031 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P 16483256, 30530841, 16407108, ...15790957
Y2038 Phosphorylation PhosphoSitePlus
S2073 Phosphorylation PhosphoSitePlus
K2136 Methylation PhosphoSitePlus
K2140 Methylation PhosphoSitePlus
K2191 Acetylation PhosphoSitePlus
Y2202 Phosphorylation PhosphoSitePlus
S2363 Phosphorylation PhosphoSitePlus
S2368 Phosphorylation PhosphoSitePlus
Y2519 Phosphorylation PhosphoSitePlus
T2522 Phosphorylation PhosphoSitePlus
T2529 Phosphorylation PhosphoSitePlus
S2751 Phosphorylation PhosphoSitePlus
T2781 Phosphorylation PhosphoSitePlus
S2808 Phosphorylation P17612 (PRKACA) , Q9UQM7 (CAMK2A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 14514795, 10830164, 16709901, ...35356048, 28131631, 22456474, 30219899, 35885069, 17606610, 20056922, 30399185, 30356673, 16407108, 15790957, 24778430, 16483256, 16626281, 14715536, 27647848, 17643448
S2814 Phosphorylation Q9UQM7 (CAMK2A) , Q13557 (CAMK2D) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26695843, 29235522, 17234969, ...28131631, 14556649, 30219899, 22511749, 20056922, 30399185, 30356673, 22509897, 20479242, 24778430, 17239900, 23071315, 32948795, 27647848, 17643448
Y2923 Phosphorylation PhosphoSitePlus
Y3285 Phosphorylation PhosphoSitePlus
S3303 Phosphorylation PhosphoSitePlus
Y3367 Phosphorylation PhosphoSitePlus
Y3370 Phosphorylation PhosphoSitePlus
S3437 Phosphorylation PhosphoSitePlus
K3438 Methylation PhosphoSitePlus
K3441 Methylation PhosphoSitePlus
Y3459 Phosphorylation PhosphoSitePlus
S3497 Phosphorylation PhosphoSitePlus
T3501 Phosphorylation PhosphoSitePlus
S3713 Phosphorylation PhosphoSitePlus
T3751 Phosphorylation PhosphoSitePlus
T3758 Phosphorylation PhosphoSitePlus
Y3780 Phosphorylation PhosphoSitePlus
K4040 Acetylation PhosphoSitePlus
K4050 Acetylation PhosphoSitePlus
S4311 Phosphorylation PhosphoSitePlus
S4317 Phosphorylation PhosphoSitePlus
Y4391 Phosphorylation PhosphoSitePlus
K4452 Acetylation PhosphoSitePlus
K4454 Acetylation PhosphoSitePlus
K4457 Acetylation PhosphoSitePlus
K4459 Acetylation PhosphoSitePlus
S4550 Phosphorylation PhosphoSitePlus
S4622 Phosphorylation PhosphoSitePlus
S4695 Phosphorylation PhosphoSitePlus
Y4705 Phosphorylation PhosphoSitePlus
T4752 Phosphorylation PhosphoSitePlus
T4755 Phosphorylation PhosphoSitePlus
S4758 Phosphorylation PhosphoSitePlus
T4761 Phosphorylation PhosphoSitePlus
Y4779 Phosphorylation PhosphoSitePlus
Y4944 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2751 Phosphorylation HPRD 19413330
S2808 Phosphorylation P17612 (PRKACA) HPRD 10830164


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K390 N390 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S406 P406 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S406 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S406 L406 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1172 N1172 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T1172 I1172 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1317 M1317 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S1483 R1483 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y1486 H1486 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1890 N1890 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1890 T1890 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K1897 N1897 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1903 Q1903 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1944 C1944 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1962 A1962 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y2038 C2038 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2073 T2073 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2073 F2073 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K2140 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S2363 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S2363 T2363 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y2519 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T2522 I2522 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T2529 S2529 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T2529 K2529 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T2781 A2781 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2814 F2814 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y2923 N2923 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S3303 F3303 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y3370 F3370 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K3438 R3438 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3497 R3497 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T3501 N3501 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T3751 N3751 Biomuta DOID:1324 / lung cancer [ cosmic ]
S4311 C4311 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S4311 N4311 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S4317 R4317 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y4391 S4391 Biomuta DOID:1324 / lung cancer [ cosmic ]
S4550 C4550 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S4695 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T4761 N4761 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y4779 C4779 Biomuta DOID:9256 / colorectal cancer [ cosmic ]