iPTMnet Report for Q92729 (PTPRU)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92729 / PTPRU_HUMAN
Protein Name Receptor-type tyrosine-protein phosphatase U precursor
Gene Name Name: PTPRU
Synonyms:FMI,PCP2,PTPRO;
Organism Homo sapiens (Human)

PRO ID PR:Q92729
DAG View
PRO Name receptor-type tyrosine-protein phosphatase U (human)
Definition A receptor-type tyrosine-protein phosphatase U that is encoded in the genome of human.
Short Label hPTPRU
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92729 (PTPRU) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N75 N-Glycosylation GlyGen 23090970, 24190977
N134 N-Glycosylation GlyGen 23090970, 24190977
S207 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
N410 N-Glycosylation GlyGen 23090970, 24190977
K440 Ubiquitination PhosphoSitePlus
Y524 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
Y563 Phosphorylation PhosphoSitePlus
Y625 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus   UniProt 19690332
S853 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S863 Phosphorylation PhosphoSitePlus
Y865 Phosphorylation PhosphoSitePlus
T867 Phosphorylation PhosphoSitePlus
Y925 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S853 Phosphorylation HPRD 19413330, 18578522, 19664994
Site PTM Type PTM Enzyme Score Source PMID
S843 Phosphorylation HPRD 19413330, 18578522, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S710 N710 Biomuta DOID:4159 / skin cancer [ cosmic ]
S843 F843 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S853 F853 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S863 F863 Biomuta DOID:4159 / skin cancer [ cosmic ]
T867 M867 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]