iPTMnet Report for Q92692 (NECTIN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92692 / NECT2_HUMAN
Protein Name Nectin-2 precursor
Gene Name Name: NECTIN2
Synonyms:HVEB,PRR2,PVRL2;
Organism Homo sapiens (Human)

PRO ID PR:Q92692
DAG View
PRO Name nectin-2 (human)
Definition A nectin-2 that is encoded in the genome of human.
Short Label hNECTIN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92692 (NECTIN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S95 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S95 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S107 O-Glycosylation GlyGen 25813380
S111 O-Glycosylation GlyGen 25813380
N137 N-Glycosylation GlyGen 29741879
T172 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
T292 O-Glycosylation GlyGen 25813380
T352 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus   UniProt 24275569
K412 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S433 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
K436 Ubiquitination PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
C446 Methylation IEDB 31844290
T447 Phosphorylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
G465 Phosphorylation UniProt 24275569
G470 Phosphorylation UniProt 24275569
S491 Phosphorylation PhosphoSitePlus
Y505 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
Y537 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S405 Phosphorylation HPRD 20166139
T410 Phosphorylation HPRD 20166139
S433 Phosphorylation HPRD 17081983, 20068231
S520 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
K411 Acetylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S185 F185 Biomuta DOID:4159 / skin cancer [ cosmic ]
T292 M292 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S405 F405 Biomuta DOID:4159 / skin cancer [ cosmic ]
T447 S447 Biomuta DOID:11934 / head and neck cancer [ icgc ]
T459 I459 Biomuta DOID:4159 / skin cancer [ cosmic ]
S491 F491 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y513 C513 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S524 F524 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ]