iPTMnet Report for Q92673 (SORL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92673 / SORL_HUMAN
Protein Name Sortilin-related receptor precursor
Gene Name Name: SORL1
Synonyms:C11orf32;
Organism Homo sapiens (Human)

PRO ID PR:Q92673
DAG View
PRO Name sortilin-related receptor (human)
Definition A sortilin-related receptor that is encoded in the genome of human.
Short Label hSORL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92673 (SORL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation PhosphoSitePlus
N99 N-Glycosylation GlyGen   UniProt 19159218, 24190977
N103 N-Glycosylation GlyGen 24190977
S114 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
Y136 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
N158 N-Glycosylation GlyGen 23090970, 29741879, 24190977
K229 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
S318 Phosphorylation HPRD 20068231
S322 Phosphorylation HPRD 20068231
S329 Phosphorylation HPRD 20068231
N367 N-Glycosylation GlyGen 24190977
N368 N-Glycosylation GlyGen 24190977
S375 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
N430 N-Glycosylation GlyGen 24190977
K446 Ubiquitination PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T598 Phosphorylation PhosphoSitePlus
N616 N-Glycosylation GlyGen 24190977
K648 Ubiquitination PhosphoSitePlus
N674 N-Glycosylation GlyGen 23090970, 24190977
K730 Ubiquitination PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus
T785 Phosphorylation PhosphoSitePlus
N871 N-Glycosylation GlyGen 23090970, 29741879, 24190977
C942 Methylation IEDB 31844290
K988 Ubiquitination PhosphoSitePlus
N1036 N-Glycosylation GlyGen 24190977
N1068 N-Glycosylation GlyGen 29741879, 24190977
N1069 N-Glycosylation GlyGen 24190977
N1164 N-Glycosylation GlyGen 23090970, 24190977
N1181 N-Glycosylation GlyGen 24190977
N1191 N-Glycosylation GlyGen 24190977
T1198 O-Glycosylation GlyGen 30459171
N1203 N-Glycosylation GlyGen 24190977
N1246 N-Glycosylation GlyGen 23090970, 24190977
S1412 O-Glycosylation GlyGen 30459171
T1413 O-Glycosylation GlyGen 30459171
T1418 O-Glycosylation GlyGen 30459171
T1460 O-Glycosylation GlyGen 30459171
S1463 O-Glycosylation GlyGen 30459171
T1464 O-Glycosylation GlyGen 30459171
K1489 Ubiquitination PhosphoSitePlus
T1508 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
C1527 Methylation IEDB 31844290
K1580 Ubiquitination PhosphoSitePlus
S1583 Phosphorylation PhosphoSitePlus
N1608 N-Glycosylation GlyGen 29741879, 24190977
K1609 Ubiquitination PhosphoSitePlus
N1611 N-Glycosylation GlyGen 24190977
K1634 Ubiquitination PhosphoSitePlus
N1706 N-Glycosylation GlyGen 23090970, 24190977
Y1719 Phosphorylation PhosphoSitePlus
N1733 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
N1809 N-Glycosylation GlyGen 24190977
T1811 Phosphorylation PhosphoSitePlus
T1824 Phosphorylation PhosphoSitePlus
N1854 N-Glycosylation GlyGen 23090970, 29741879, 24190977
C1860 Methylation IEDB 31844290
Y1874 Phosphorylation PhosphoSitePlus
T1876 Phosphorylation PhosphoSitePlus
N1894 N-Glycosylation GlyGen 23090970, 29741879, 24190977
K1970 Methylation IEDB 34433824
Y1980 Phosphorylation PhosphoSitePlus
S1984 Phosphorylation PhosphoSitePlus
N1986 N-Glycosylation GlyGen 23090970, 24190977
S1987 Phosphorylation PhosphoSitePlus
Y2002 Phosphorylation PhosphoSitePlus
N2010 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
N2054 N-Glycosylation GlyGen 29741879, 24190977
N2076 N-Glycosylation GlyGen   UniProt 19159218
N2092 N-Glycosylation GlyGen   UniProt 19159218, 24190977
Y2159 Phosphorylation PhosphoSitePlus
T2160 Phosphorylation PhosphoSitePlus
S2167 Phosphorylation PhosphoSitePlus
S2179 Phosphorylation IEDB 32357974
S2183 Phosphorylation IEDB   PhosphoSitePlus 32357974
S2206 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21147781
S2206 Phosphorylation O75116 (ROCK2) PhosphoSitePlus 21147781


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92673 (SORL1) S2206 Q9UJY5 (GGA1) unknown eFIP 22621900


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S149 L149 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S149 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K305 T305 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
N368 S368 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S375 P375 Biomuta DOID:363 / uterine cancer [ cosmic ]
S499 L499 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T598 I598 Biomuta DOID:4159 / skin cancer [ cosmic ]
N674 K674 Biomuta DOID:263 / kidney cancer [ cosmic ]
K730 E730 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K730 N730 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T779 I779 Biomuta DOID:4159 / skin cancer [ cosmic ]
N1203 K1203 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1412 L1412 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1418 M1418 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1609 N1609 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1609 T1609 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N1706 D1706 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
N1733 S1733 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1811 A1811 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1876 M1876 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1970 N1970 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N2010 S2010 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2206 L2206 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]