Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92667 / AKAP1_HUMAN
Protein Name A-kinase anchor protein 1, mitochondrial precursor
Gene Name Name: AKAP1
Synonyms:AKAP149,PRKA1;
Organism Homo sapiens (Human)

PRO ID PR:Q92667
DAG View
PRO Name A-kinase anchor protein 1, mitochondrial (human)
Definition An A-kinase anchor protein 1, mitochondrial that is encoded in the genome of human.
Short Label hAKAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92667 (AKAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K55 Ubiquitination PhosphoSitePlus
C64 S-Nitrosylation dbSNO 26338901
S69 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S73 Phosphorylation PhosphoSitePlus
S105 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S107 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S108 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S128 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S158 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S169 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K213 Ubiquitination PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
K440 Methylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S445 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T447 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648
T533 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...24275569, 19690332, 20068231
S573 Phosphorylation PhosphoSitePlus   UniProt 24275569
S577 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus   UniProt 24275569
S592 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S600 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K800 Ubiquitination PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
Y900 Phosphorylation PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T70 Phosphorylation HPRD 19413330, 19007248, 20068231
S105 Phosphorylation HPRD 18669648
S107 Phosphorylation HPRD 18669648
S108 Phosphorylation HPRD 18669648
S151 Phosphorylation HPRD 19413330, 19415658, 20068231
S169 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 18077418
S357 Phosphorylation HPRD 18077418
T360 Phosphorylation HPRD 18077418
T366 Phosphorylation HPRD 18077418
S441 Phosphorylation HPRD 20068231
S445 Phosphorylation HPRD 18669648, 19664995
T447 Phosphorylation HPRD 18669648, 20068231
T533 Phosphorylation HPRD 19413330, 15302935, 19664995, ...18452278, 18669648, 20166139, 20068231
S592 Phosphorylation HPRD 19651622, 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S105 * Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S142 L142 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S150 L150 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S151 F151 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S235 G235 Biomuta DOID:263 / kidney cancer [ tcga ]
S429 L429 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S441 I441 Biomuta DOID:3571 / liver cancer [ icgc ]
T533 P533 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K666 R666 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]