iPTMnet Report for Q92630 (DYRK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92630 / DYRK2_HUMAN
Protein Name Dual specificity tyrosine-phosphorylation-regulated kinase 2
Gene Name Name: DYRK2
Organism Homo sapiens (Human)

PRO ID PR:Q92630
DAG View
PRO Name dual specificity tyrosine-phosphorylation-regulated kinase 2 (human)
Definition A dual specificity tyrosine-phosphorylation-regulated kinase 2 that is encoded in the genome of human.
Short Label hDYRK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92630 (DYRK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S7 Phosphorylation PhosphoSitePlus
R18 Methylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   UniProt 23186163
T44 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
T106 Phosphorylation neXtProt   PRO   PhosphoSitePlus   UniProt 19965871
T106 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus 19965871
S142 Phosphorylation PhosphoSitePlus
C347 S-Nitrosylation dbSNO 24105792
C373 S-Nitrosylation dbSNO 24105792
Y380 Phosphorylation PhosphoSitePlus
T381 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 18455992
T381 Phosphorylation Q02779 (MAP3K10) neXtProt   PhosphoSitePlus 18455992
Y382 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22998443, 18491313, 18083107, ...18669648, 9748265, 16497976, 32678104
Y382 Phosphorylation Q92630 (DYRK2) neXtProt   UniProt 9748265, 22998443, 18491313
S385 Phosphorylation PhosphoSitePlus
S442 Phosphorylation neXtProt   PRO   PhosphoSitePlus   UniProt 19965871
S442 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus 19965871
S449 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 18455992
S449 Phosphorylation Q02779 (MAP3K10) neXtProt   PhosphoSitePlus 18455992
Y464 Phosphorylation PhosphoSitePlus
T525 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y380 Phosphorylation HPRD 16497976
Y382 Phosphorylation HPRD 18083107, 18669648, 19664994, ...19664995, 16497976
Y464 Phosphorylation HPRD 19664995
T525 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
T32 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation HPRD 16497976
Y309 Phosphorylation HPRD   PhosphoSitePlus 19664994, 19664995, 18083107, ...18669648, 16497976
Y391 Phosphorylation HPRD 19664995
T452 Phosphorylation HPRD 19413330
S483 Phosphorylation PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus


Q92630 (DYRK2) as PTM Enzyme



Substrate Site Score Source PMID
O43255 (SIAH2) S16 neXtProt   PhosphoSitePlus   Signor 22878263
O43255 (SIAH2) T26 neXtProt   PhosphoSitePlus   Signor 22878263
O43255 (SIAH2) S28 neXtProt   PhosphoSitePlus   Signor 22878263
O43255 (SIAH2) S68 neXtProt   PhosphoSitePlus   Signor 22878263
O43255 (SIAH2) T119 neXtProt   PhosphoSitePlus   Signor 22878263
O43602-2 (DCX) S306 PhosphoSitePlus 22359282
O75449 (KATNA1) S42 neXtProt   PhosphoSitePlus   Signor 19287380
O75449 (KATNA1) S109 neXtProt   PhosphoSitePlus   Signor 19287380
O75449 (KATNA1) T133 neXtProt   PhosphoSitePlus   Signor 19287380
P04637 (TP53) S46 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17349958, 19965871
P05412 (JUN) S243 neXtProt   Signor 22307329, 20831597
P10070 (GLI2) S388 neXtProt 18455992
P10070 (GLI2) S1011 neXtProt 18455992
P10636-8 (MAPT) T212 PhosphoSitePlus 11311121
P10636 (MAPT) T529 neXtProt 11311121
P13807 (GYS1) S641 neXtProt 14593110
P43686 (PSMC4) T25 PhosphoSitePlus 26655835
Q13541 (EIF4EBP1) S65 neXtProt   PhosphoSitePlus 12588975
Q13541 (EIF4EBP1) S101 neXtProt   PhosphoSitePlus 12588975
Q14194 (CRMP1) S522 PhosphoSitePlus 16611631
Q14195 (DPYSL3) T509 Signor 16611631
Q14195 (DPYSL3) T514 Signor 16611631
Q14195 (DPYSL3) S518 Signor 16611631
Q14195 (DPYSL3) S522 neXtProt   PhosphoSitePlus 15466863, 16611631
Q16555 (DPYSL2) S522 neXtProt   PhosphoSitePlus 15466863, 16611631
Q92630 (DYRK2) Y382 neXtProt   UniProt 9748265, 22998443, 18491313
Q9UHD2 (TBK1) S527 PhosphoSitePlus 26407194
Q9Y2V2 (CARHSP1) S30 PhosphoSitePlus   Signor 15910284
Q9Y2V2 (CARHSP1) S32 PhosphoSitePlus   Signor 15910284
Q9Y2V2 (CARHSP1) S41 PhosphoSitePlus   Signor 21177848, 15910284


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047230 (hDYRK2/Phos:1) pT106,pS442 PRO
PR:000047231 (hDYRK2/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 L7 Biomuta DOID:4159 / skin cancer [ cosmic ]
R18 L18 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S30 F30 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S48 P48 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
Y307 H307 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y380 H380 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T381 M381 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S483 R483 Biomuta DOID:1612 / breast cancer [ cosmic ]
S483 G483 Biomuta DOID:1612 / breast cancer [ cosmic ]
T484 P484 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S497 A497 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S499 P499 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]